SPC25 and SPC24

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SPC25	SPC24
Description		SPC25 component of NDC80 kinetochore complex	SPC24 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleus Cytosol Ndc80 Complex	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitotic Spindle Organization Chromosome Segregation Cell Division	Cell Cycle Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Circulating leptin levels or HOMA-B ( 32341051) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Fasting blood glucose ( 29621232) Glycemic traits (pleiotropy) ( 31021400) Granulocyte count ( 27863252) Height ( 28552196) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Apolipoprotein A1 levels ( 32203549) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)
Interacting Genes		4 interacting genes: HGS NDC80 SEC61B SPC24	8 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SPC25 SUOX WHRN
Entrez ID		57405	147841
HPRD ID		15465	15464
Ensembl ID		ENSG00000152253	ENSG00000161888
Uniprot IDs		Q9HBM1	B4E086 Q8NBT2
PDB IDs		2VE7 3IZ0	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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