CCNL1 and JMJD6

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CCNL1	JMJD6
Description		cyclin L1	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Speck	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II RNA Processing	Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation
Pathways			HDMs demethylate histones
Drugs
Diseases
GWAS		Adiponectin levels in pregnancy ( 28317342) Adult body size ( 32376654) Anthropometric traits in newborns ( 23575227) Birth weight ( 23202124 31453325 31043758 27680694 20372150) Birth weight variance ( 31453325) Body fat percentage variance ( 31453325) Body mass index ( 26426971) circulating leptin levels ( 32917775 26833098) circulating leptin levels adjusted for BMI ( 32917775 26833098) Coronary artery disease ( 33020668) Diabetic retinopathy ( 21441570) Eating disorders ( 22911880) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Menarche (age at onset) ( 25231870) Offspring birth weight ( 31043758) PR interval ( 30046033 32439900) Smoking cessation in chronic obstructive pulmonary disease ( 21685187)	Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		22 interacting genes: APP APPBP2 C1orf35 CASP8 CDK11A DVL3 FAM133A JMJD6 KRTAP12-2 NKAPD1 PRDM6 PRPF40A RAD51D RNPS1 RSRP1 SAP30BP SORBS3 SREK1IP1 SRSF2 TFIP11 ZRANB1 ZRSR2	27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		57018	23210
HPRD ID		10814	05371
Ensembl ID		ENSG00000163660	ENSG00000070495
Uniprot IDs		Q9UK58	Q6NYC1
PDB IDs			3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?
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