ACTN1 and MYOZ1

Data Source:
HPRD (in vivo)

		ACTN1	MYOZ1
Description		actinin alpha 1	myozenin 1
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Extracellular Region Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Cell-cell Junction Fascia Adherens Focal Adhesion Z Disc Platelet Alpha Granule Lumen Pseudopodium Cell Projection Extracellular Exosome Glutamatergic Synapse	Nucleus Actin Cytoskeleton Z Disc Pseudopodium
	Molecular Function	Double-stranded RNA Binding Integrin Binding Calcium Ion Binding Protein Binding Vinculin Binding Nuclear Receptor Coactivator Activity Protein Homodimerization Activity Ion Channel Binding Actin Filament Binding Structural Constituent Of Postsynapse	Actin Binding Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Telethonin Binding FATZ Binding
	Biological Process	Platelet Degranulation Actin Filament Organization Platelet Activation Platelet Formation Platelet Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Focal Adhesion Assembly Actin Filament Bundle Assembly Negative Regulation Of Cellular Component Movement Actin Filament Network Formation Platelet Aggregation Postsynapse Organization	Negative Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Myofibril Assembly Negative Regulation Of Phosphoprotein Phosphatase Activity Wound Healing Negative Regulation Of Skeletal Muscle Tissue Regeneration Skeletal Muscle Fiber Adaptation Sarcomere Organization Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Platelet degranulation Syndecan interactions Nephrin family interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs		Human calcitonin Copper
Diseases
GWAS		Asthma ( 31959851) Cognitive decline rate in late mild cognitive impairment ( 26252872) Feeling fed-up ( 29500382) Feeling hurt ( 29500382) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) High light scatter reticulocyte count ( 32888494) Lack of perseverance ( 30718321) Mean platelet volume ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Mosquito bite size ( 28199695) Neurociticism ( 29500382) Periodontitis (Mean PAL) ( 24024966) Platelet count ( 26805783 29403010 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Prostate cancer ( 23535732) Rheumatoid arthritis (ACPA-positive) ( 23143596) Smoking behavior ( 19247474) Urinary albumin excretion ( 30220432)	Atrial fibrillation ( 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		90 interacting genes: ACTN2 ACTN3 ADORA2A APC APPBP2 ATXN2 ATXN7 C14orf119 CACNA1A CAMK2A CBY2 CDK5 CDK5R1 CDK5R2 CLIC5 COIL COL17A1 CSRP1 CSRP3 CTNNA1 DDIAS DYNLT1 EIF2S1 EPM2AIP1 ERBIN FBP1 FXN GADD45G GFI1B GIPC1 GIT2 GRIA4 GRIN2A GRM5 GTF2H1 HSPB1 ICAM5 ITGB1 KAT2B KCTD6 KPNA2 LINC01554 LNX1 LPP MAGEA11 MAP2 MAP3K1 MED14 MICALL2 MTDH MTNR1A MTNR1B MYOT MYOZ1 MYOZ2 MYOZ3 NEBL NKAPD1 NR1H3 NUMBL OAS1 PALLD PDHX PDLIM1 PDLIM5 PIAS4 PKD1 PKN1 PLD2 PSEN1 PSMA1 PTK2 PTPN1 PTPN6 PYGB RAVER1 RPS27 SIRPA SLC2A4 SORBS2 SRC SSX2IP SYNPO2L TES TTN TXN USP2 VCL XRCC4 ZYX	40 interacting genes: ACTN1 ACTN2 ACTN3 ACTN4 AKAP8L APP BAG4 BRCA1 CEACAM6 CEP76 CRX EIF3F EXOSC8 FLNA FLNC GOLGA6A GRB2 KRT34 KRT36 KRTAP12-2 LDB3 LHX4 LZTS2 MAGEA11 PFDN5 PLEKHG4 PNKP PNMA1 PRKAA2 TCAP TRAF1 TRIM23 TRIM55 TRIM63 USHBP1 VAC14 VBP1 WASHC3 WWOX YPEL3
Entrez ID		87	58529
HPRD ID		00020	05725
Ensembl ID		ENSG00000072110	ENSG00000177791
Uniprot IDs		A0A024R694 P12814	Q9NP98
PDB IDs		2EYI 2EYN 2N8Y 2N8Z
Enriched GO Terms of Interacting Partners?
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