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ATF2 and MACROH2A1
Data Source:
BioGRID
(pull down)
ATF2
MACROH2A1
Description
activating transcription factor 2
macroH2A.1 histone
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Site Of Double-strand Break
H4 Histone Acetyltransferase Complex
Nuclear Chromosome
Chromosome, Telomeric Region
Chromatin
Nucleosome
Condensed Chromosome
Sex Chromatin
Barr Body
Nucleus
Nucleoplasm
Pericentric Heterochromatin
Nucleolus
Extracellular Exosome
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Activating Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Histone Acetyltransferase Activity
Protein Binding
CAMP Response Element Binding Protein Binding
H4 Histone Acetyltransferase Activity
Protein Kinase Binding
CAMP Response Element Binding
H2B Histone Acetyltransferase Activity
Protein-containing Complex Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
RDNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA Binding
Protein Binding
Double-stranded Methylated DNA Binding
Enzyme Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Chromatin DNA Binding
Nucleosomal DNA Binding
Protein Heterodimerization Activity
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Response To Osmotic Stress
Cellular Response To DNA Damage Stimulus
Response To Water Deprivation
Positive Regulation Of Gene Expression
Negative Regulation Of Angiogenesis
Intra-S DNA Damage Checkpoint
Positive Regulation Of Transforming Growth Factor Beta2 Production
Positive Regulation Of Neuron Apoptotic Process
Histone H4 Acetylation
Histone H2B Acetylation
Fat Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Adipose Tissue Development
Amelogenesis
Positive Regulation Of Cardiac Muscle Myoblast Proliferation
Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nucleosome Assembly
Chromatin Silencing
Dosage Compensation
Regulation Of Lipid Metabolic Process
Negative Regulation Of Histone Phosphorylation
Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion
Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Keratinocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K27 Methylation
Regulation Of Ribosomal DNA Heterochromatin Assembly
Establishment Of Protein Localization To Chromatin
Negative Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Negative Regulation Of Cell Cycle G2/M Phase Transition
Regulation Of Response To Oxidative Stress
Positive Regulation Of Endodermal Cell Differentiation
Negative Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways
Transcriptional activation of mitochondrial biogenesis
HATs acetylate histones
Circadian Clock
Activation of the AP-1 family of transcription factors
TP53 Regulates Transcription of DNA Repair Genes
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
NGF-stimulated transcription
NGF-stimulated transcription
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs
Pseudoephedrine
Diseases
GWAS
Intake of total sugars (
31005972
)
Metabolite levels (
23823483
)
Interacting Genes
63 interacting genes:
APP
AR
ATF3
ATF4
ATF7
BACH1
BANP
BATF
CCDC6
CCND1
CEBPA
CEBPB
CEBPG
CENPQ
CREB5
CSNK2A1
CSNK2A2
DDIT3
DNMT3L
EDF1
ETS1
EXOSC8
FOS
FOSB
FOSL1
FOSL2
GTF2F2
H2BC21
HMGA1
IRF2BP1
JDP2
JUN
KIFC3
LHX8
MACROH2A1
MAPK1
MAPK10
MAPK11
MAPK13
MAPK14
MAPK8
MAPK9
MAPKAPK5
MLH1
NBN
NCOA6
PIAS2
PML
PRKCE
RB1
RNF4
RPS6KA5
RUVBL2
SMAD3
SMAD4
SPOPL
SRA1
SUMO1
THRB
UBE2I
UTF1
XPO1
YY1
20 interacting genes:
APP
ATF2
ATXN1L
BARD1
BRCA1
CYSRT1
ERICH2
FAM133A
H2BC15
KRTAP10-8
NKAPD1
PARP1
SPOP
SREK1IP1
SRPK1
TRAF2
TRIM26
TRIM59
VCX2
ZNF622
Entrez ID
1386
9555
HPRD ID
00443
13624
Ensembl ID
ENSG00000115966
ENSG00000113648
Uniprot IDs
A4D7V5
P15336
O75367
PDB IDs
1BHI
1T2K
4H36
1U35
1ZR3
1ZR5
2F8N
2FXK
3HQH
3HSV
3IID
3IIF
3IVB
5IIT
5LNC
Enriched GO Terms of Interacting Partners
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