ATF2 and CREB5

Data Source:
HPRD (in vitro)

		ATF2	CREB5
Description		activating transcription factor 2	cAMP responsive element binding protein 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Site Of Double-strand Break H4 Histone Acetyltransferase Complex	Chromatin Nucleus Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding H4 Histone Acetyltransferase Activity Protein Kinase Binding CAMP Response Element Binding H2B Histone Acetyltransferase Activity Protein-containing Complex Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Response To Water Deprivation Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Intra-S DNA Damage Checkpoint Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Neuron Apoptotic Process Histone H4 Acetylation Histone H2B Acetylation Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Adipose Tissue Development Amelogenesis Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated
Pathways		Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Circadian Clock Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs		Pseudoephedrine
Diseases
GWAS		Intake of total sugars ( 31005972) Metabolite levels ( 23823483)	Adolescent idiopathic scoliosis ( 31417091) Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Anxiety in major depressive disorder ( 24047446) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 30061737 29892015) Attention deficit hyperactivity disorder ( 18839057) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Crohn's disease ( 23128233) Diabetic retinopathy ( 21441570) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Pre-treatment viral load in HIV-1 infection ( 31219150) Pulse pressure ( 27841878 30578418) Serum thyroid-stimulating hormone levels ( 25436638) Smoking behaviour (cigarettes smoked per day) ( 31217584) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) TPE interval (resting) ( 32386560) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 29403010 32888494 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		63 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BANP BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CENPQ CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FOS FOSB FOSL1 FOSL2 GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 LHX8 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PIAS2 PML PRKCE RB1 RNF4 RPS6KA5 RUVBL2 SMAD3 SMAD4 SPOPL SRA1 SUMO1 THRB UBE2I UTF1 XPO1 YY1	132 interacting genes: ADAMTSL4 AJUBA AKAP8L ALPP ANAPC11 ATF2 BATF3 CDPF1 CERCAM CIB4 CNFN COL8A1 CYP21A2 CYSRT1 EFEMP2 FBLN1 FHL3 FOS FOSB FOSL1 FOSL2 FRS3 FST HOXA1 HSD3B7 ID3 IGFBP6 INTS11 JDP2 JUN KIFC3 KPRP KRT15 KRT31 KRT40 KRT83 KRT85 KRT86 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP19-2 KRTAP19-3 KRTAP19-5 KRTAP19-6 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP8-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1C LCE2A LCE2C LCE4A LCE5A LGALS13 LITAF LMX1B MDFI MGAT5B MLLT6 MMADHC MTUS2 NADSYN1 NBPF19 NOTCH2NLA PCSK5 PLA2G10 PRDM14 PRR22 RBCK1 RBP3 RBPMS RCHY1 RGS17 RGS20 RIMBP3 RNF144B RNF208 SIVA1 SNAPC5 SPATA12 SPOP SPOPL SPRED1 SPRY1 SPRY2 SPRY3 SPRY4 SSC4D TP53BP1 TRAF2 TRIM23 TRIM27 TRIM42 TRIP6 TSGA10 TSPAN4 TSR2 UFSP1 UNKL WWOX ZMAT5 ZNF330
Entrez ID		1386	9586
HPRD ID		00443	09896
Ensembl ID		ENSG00000115966	ENSG00000146592
Uniprot IDs		A4D7V5 P15336	Q02930
PDB IDs		1BHI 1T2K 4H36
Enriched GO Terms of Interacting Partners?
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