GSTP1 and KRT31

Data Source:
BioGRID (two hybrid, two hybrid)

		GSTP1	KRT31
Description		glutathione S-transferase pi 1	keratin 31
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Vesicle Secretory Granule Lumen Extracellular Exosome TRAF2-GSTP1 Complex Ficolin-1-rich Granule Lumen	Extracellular Space Cytosol Intermediate Filament Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Fatty Acid Binding Protein Binding Drug Binding JUN Kinase Binding Kinase Regulator Activity S-nitrosoglutathione Binding Dinitrosyl-iron Complex Binding Glutathione Binding Nitric Oxide Binding	Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Response To Reactive Oxygen Species Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Protein Kinase Activity Prostaglandin Metabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Central Nervous System Development Negative Regulation Of Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Oligodendrocyte Development Animal Organ Regeneration Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation Response To L-ascorbic Acid Cellular Response To Oxidative Stress Common Myeloid Progenitor Cell Proliferation Nitric Oxide Storage Negative Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of JUN Kinase Activity Linoleic Acid Metabolic Process Response To Ethanol Negative Regulation Of Fibroblast Proliferation Hepoxilin Biosynthetic Process Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Cell-matrix Adhesion Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Smooth Muscle Cell Chemotaxis Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cytoskeleton Organization Epidermis Development Keratinization Cornification
Pathways		Glutathione conjugation Detoxification of Reactive Oxygen Species Neutrophil degranulation	Keratinization Formation of the cornified envelope
Drugs		Glutathione Troglitazone Clozapine Etacrynic acid Clomipramine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene S-Hydroxycysteine Cibacron Blue Glutathione sulfonic acid Glutathione disulfide Deoxycholic acid S-(4-nitrobenzyl)glutathione 2-(N-morpholino)ethanesulfonic acid S-Hexylglutathione Carbocisteine Canfosfamide Ezatiostat Exisulind S-NONYL-CYSTEINE S-(4-BROMOBENZYL)CYSTEINE Curcumin Dinitrochlorobenzene Hypericin Curcumin sulfate
Diseases		Prostate cancer
GWAS		Blood protein levels ( 29875488) Refractive error ( 32231278)	Brown vs. black hair color ( 30531825)
Interacting Genes		35 interacting genes: ADAMTSL4 APPBP2 CARD10 CYSRT1 FANCC FHL5 HOXA1 KRT31 KRT33B KRT34 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP3-1 KRTAP3-3 KRTAP6-2 LRP2BP MAPK8 MLH1 MTUS2 NBPF19 NOTCH2NLA PNO1 PRDX6 PTN SCAF1 SH3GLB1 SUMO4 TGM1 TGM2 TRAF2 ZNF655	356 interacting genes: A1CF ABI2 ABI3 ABL1 ACTR10 AGR2 AGXT AIMP2 AKR7A3 ALDH3B1 AMOT AMOTL2 ANKRD36BP1 ANKS1A AQP1 AQP5 ARHGAP35 ARID3A ARMC7 ARSJ ASMTL ASPSCR1 ATG9A ATN1 ATXN7L1 ATXN7L2 AVPI1 B4GALT7 BAD BCAS2 BEX1 BEX2 BFSP2 BHLHA9 BRME1 BTC BYSL C19orf73 C1orf109 C1orf216 C2CD6 C3 C5orf49 C5orf60 CA6 CARD9 CATIP CATSPER1 CBX8 CCDC112 CCDC116 CCDC120 CCDC146 CCDC17 CCDC187 CCDC196 CCDC198 CCDC93 CCER1 CCHCR1 CCNC CD33 CDC20B CDK18 CDKN1A CDKN2C CDR2L CEP57 CEP57L1 CEP70 CFAP206 CFAP53 CHCHD2 CHRNG CLCNKA CLDN19 CLDN2 CLEC18A CNNM3 CNTF COA5 COMT COX5A COX5B CRACR2A CREB5 CRH CTSG CXCL16 CYSRT1 DEF6 DGCR6L DHX37 DMRT3 DOCK2 DTNB EIF4E2 EIF4G1 ENKD1 EPDR1 EXOC8 EXOSC5 FADS2 FAM110A FAM124B FAM50B FAM71C FAM74A4 FAM90A1 FARS2 FBF1 FBXW5 FGF16 FKBP1B FOXB1 FRS3 GAD1 GADD45GIP1 GEM GFAP GFOD1 GLRX3 GNAI2 GNE GNG10 GNG5 GOLGA6L2 GPS2 GSTP1 HAPLN2 HAUS1 HBA1 HBA2 HBZ HCK HDAC4 HGS HNRNPLL HOXA1 HOXB5 HS6ST1 HSD3B7 HSF4 HSPA12B HSPD1 HYAL2 ICAM4 IL16 INPP5D INPP5K INSR ITGB2 ITGB4 ITGB5 JOSD1 KCTD9 KDM1A KIAA1217 KIFC3 KLC1 KLC4 KLHL38 KLK8 KRT1 KRT2 KRT20 KRT3 KRT4 KRT5 KRT6A KRT6B KRT6C KRT71 KRT72 KRT73 KRT74 KRT75 KRT76 KRT77 KRT78 KRT79 KRT8 KRT80 KRT81 KRT82 KRT83 KRT85 KRT86 KRTAP4-12 KRTAP5-6 KRTAP9-2 KRTAP9-3 LATS1 LCE1B LCE3C LCE3D LCE3E LCE4A LENG1 LIF LIN37 LINC00526 LMF2 LMNTD2 LMO3 LMO4 LONRF1 LRRC41 MAB21L2 MAP3K7CL MAPKBP1 MARK4 MID2 MOS MRPL40 MSRB3 MTA1 MXD3 MXI1 MYOM1 NAV1 NAXD NEK6 NODAL NPBWR2 NTAQ1 NUDT16L1 NUFIP2 OTUB2 OTX1 P2RX7 P3H3 PBX3 PDE4DIP PDGFRB PGAP6 PGLS PHC2 PHLDA1 PIN1 PKN1 PKN3 PKP2 PLEKHN1 POLDIP3 POU4F2 POU4F3 PPP1R18 PPP1R32 PRF1 PRKAA2 PRKAB2 PRPF18 PRPF31 PRPH PRR19 PRR35 PSMA1 PSMB1 PSMC5 PSMG2 PSPC1 PTGER3 PTPMT1 R3HDM2 RAB33A RADIL RAMAC RCOR3 RHPN1 RIBC1 RPS19BP1 RPUSD3 RSPH14 RTP5 SAMD11 SCNM1 SEC14L4 SEMA4C SHC3 SHFL SHISA6 SIRPA SLC15A3 SLC23A1 SLC25A42 SLC25A6 SMARCD1 SMARCE1 SMCP SMG9 SNAI1 SNRNP25 SPATA24 SPG21 SPON2 SPRING1 SPRY1 SRSF2 SSX2IP STK16 TACO1 TAPBPL TCEANC TEAD4 TEPSIN TEX28 TEX33 TFAP2D THAP7 TLE5 TMEM106C TMEM174 TMEM231 TMSB4X TRAF4 TRIML2 TROAP TSEN54 TSG101 TSHZ3 TSNAX TTC23 TTC9C TXLNA TYK2 UACA UBASH3A USHBP1 USP2 UTP23 UXT VASN VPS9D1 WDR25 WFDC6 ZDHHC1 ZFHX3 ZFYVE21 ZGPAT ZIC1 ZNF124 ZNF148 ZNF20 ZNF250 ZNF414 ZNF417 ZNF446 ZNF564 ZNF569 ZNF572 ZNF587 ZNF688 ZNF69 ZNF835 ZNRF2P1
Entrez ID		2950	3881
HPRD ID		00614	03047
Ensembl ID		ENSG00000084207	ENSG00000094796
Uniprot IDs		P09211 V9HWE9	Q15323
PDB IDs		10GS 11GS 12GS 13GS 14GS 16GS 17GS 18GS 19GS 1AQV 1AQW 1AQX 1EOG 1EOH 1GSS 1KBN 1LBK 1MD3 1MD4 1PGT 1PX6 1PX7 1ZGN 20GS 22GS 2A2R 2A2S 2GSS 2J9H 2PGT 3CSH 3CSI 3CSJ 3DD3 3DGQ 3GSS 3GUS 3HJM 3HJO 3HKR 3IE3 3KM6 3KMN 3KMO 3N9J 3PGT 4GSS 4PGT 5DAK 5DAL 5DCG 5DDL 5DJL 5DJM 5GSS 5J41 5JCW 5L6X 5X79 6AP9 6GSS 6Y1E 7GSS 8GSS 9GSS
Enriched GO Terms of Interacting Partners?
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