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PRKCD and DAB2
Data Source:
HPRD
(in vitro)
PRKCD
DAB2
Description
protein kinase C delta
DAB adaptor protein 2
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Fibrillar Center
Cytoplasm
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Clathrin-coated Vesicle
Clathrin-coated Vesicle Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Calcium-independent Protein Kinase C Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Binding
Protein C-terminus Binding
Clathrin Adaptor Activity
Cargo Receptor Activity
SMAD Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Cell Cycle
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Signaling Receptor Activity
Immunoglobulin Mediated Immune Response
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Termination Of Signal Transduction
Platelet Activation
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of MRNA Stability
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Phosphorylation
Receptor-mediated Endocytosis
Apoptotic Process
Integrin-mediated Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Protein Transport
Wnt Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Leading Edge Cell Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Membrane Organization
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Clathrin-dependent Endocytosis
Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
Gap junction degradation
Formation of annular gap junctions
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Drugs
Tamoxifen
13-Acetylphorbol
Ingenol mebutate
Fostamatinib
Diseases
GWAS
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
29403010
)
Birth weight (
31043758
)
Chronic kidney disease (
31152163
20383146
)
Creatinine levels (
31015462
)
Diverticular disease (
30177863
)
Estimated glomerular filtration rate (
31152163
31015462
31451708
30604766
)
Estimated glomerular filtration rate in diabetes (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
HDL cholesterol levels (
32203549
)
Health literacy (
31250787
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Non-albumin protein levels (
29403010
)
Pancreatic cancer (
22158540
)
Premature menopause in childhood cancer survivors (
29432556
)
Self-reported allergy (
23817569
)
Systemic lupus erythematosus (
19838195
)
Urate levels (
23263486
)
Waist-hip ratio (
28552196
)
Interacting Genes
120 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
40 interacting genes:
AP2M1
APLP1
APLP2
APP
ATXN1L
AXIN1
CDC16
CDK1
CSK
DAB2IP
DIP2A
DVL1
DVL3
FCHO1
FCHO2
FGR
GRB2
INPP5D
ITGB3
ITGB5
ITSN1
LDLR
LRP1
LRP2
LRP8
MIB1
MYO6
NECAP1
PIN1
PRKCB
PRKCD
PRKCG
SGIP1
SMAD2
SMAD3
SMURF2
SRC
SUMO2
TGFBR1
TGFBR2
Entrez ID
5580
1601
HPRD ID
01501
03139
Ensembl ID
ENSG00000163932
ENSG00000153071
Uniprot IDs
A0A024R328
B4DFV1
Q05655
A0A024R036
B2RAW0
P98082
PDB IDs
1YRK
2YUU
2LSW
6O5O
6OVF
Enriched GO Terms of Interacting Partners
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