Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
DAB2 and DVL1
Data Source:
BioGRID
(pull down)
DAB2
DVL1
Description
DAB adaptor protein 2
dishevelled segment polarity protein 1
Image
GO Annotations
Cellular Component
Fibrillar Center
Cytoplasm
Lysosomal Membrane
Cytosol
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Clathrin-coated Vesicle
Clathrin-coated Vesicle Membrane
Intracellular Membrane-bounded Organelle
Cytosol
Microtubule
Postsynaptic Density
Lateral Plasma Membrane
Clathrin-coated Vesicle
Growth Cone
Cytoplasmic Vesicle
Neuron Projection
Neuronal Cell Body
Dendritic Spine
Synapse
Schaffer Collateral - CA1 Synapse
Presynapse
Glutamatergic Synapse
Wnt Signalosome
Molecular Function
Protein Binding
Protein C-terminus Binding
Clathrin Adaptor Activity
Cargo Receptor Activity
SMAD Binding
Molecular_function
Frizzled Binding
Protein Binding
Beta-catenin Binding
Enzyme Binding
Protein Kinase Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Phosphorylation
Receptor-mediated Endocytosis
Apoptotic Process
Integrin-mediated Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Protein Transport
Wnt Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Leading Edge Cell Differentiation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Endocytosis
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Androgen Receptor Signaling Pathway
Membrane Organization
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Clathrin-dependent Endocytosis
Positive Regulation Of Early Endosome To Late Endosome Transport
Regulation Of Neurotransmitter Levels
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Negative Regulation Of Protein Kinase Activity
Neurotransmitter Secretion
Axon Guidance
Heart Development
Neuromuscular Junction Development
Positive Regulation Of Neuron Projection Development
Neural Tube Development
Convergent Extension Involved In Neural Plate Elongation
Cytoplasmic Microtubule Organization
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Social Behavior
Protein Localization To Microtubule
Intracellular Signal Transduction
Non-canonical Wnt Signaling Pathway
Receptor Clustering
Positive Regulation Of Transcription By RNA Polymerase II
Collateral Sprouting
Axon Extension
Dendrite Morphogenesis
Synapse Organization
Protein Stabilization
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Prepulse Inhibition
Dendritic Spine Morphogenesis
Skeletal Muscle Acetylcholine-gated Channel Clustering
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Presynapse Assembly
Positive Regulation Of Neuron Projection Arborization
Regulation Of Cellular Protein Localization
Beta-catenin Destruction Complex Disassembly
Positive Regulation Of Protein Localization To Presynapse
Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Gap junction degradation
Formation of annular gap junctions
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
PCP/CE pathway
PCP/CE pathway
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
29403010
)
Birth weight (
31043758
)
Chronic kidney disease (
31152163
20383146
)
Creatinine levels (
31015462
)
Diverticular disease (
30177863
)
Estimated glomerular filtration rate (
31152163
31015462
31451708
30604766
)
Estimated glomerular filtration rate in diabetes (
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
HDL cholesterol levels (
32203549
)
Health literacy (
31250787
)
Heel bone mineral density (
30598549
28869591
)
Height (
31562340
)
Non-albumin protein levels (
29403010
)
Pancreatic cancer (
22158540
)
Premature menopause in childhood cancer survivors (
29432556
)
Self-reported allergy (
23817569
)
Systemic lupus erythematosus (
19838195
)
Urate levels (
23263486
)
Waist-hip ratio (
28552196
)
Inflammatory bowel disease (
28067908
)
Nicotine dependence (
32281736
)
Ulcerative colitis (
28067908
)
Interacting Genes
40 interacting genes:
AP2M1
APLP1
APLP2
APP
ATXN1L
AXIN1
CDC16
CDK1
CSK
DAB2IP
DIP2A
DVL1
DVL3
FCHO1
FCHO2
FGR
GRB2
INPP5D
ITGB3
ITGB5
ITSN1
LDLR
LRP1
LRP2
LRP8
MIB1
MYO6
NECAP1
PIN1
PRKCB
PRKCD
PRKCG
SGIP1
SMAD2
SMAD3
SMURF2
SRC
SUMO2
TGFBR1
TGFBR2
43 interacting genes:
ANXA7
ARRB1
ATN1
AXIN1
BAG3
BRD7
BUB1
CCDC88C
CSNK1D
CSNK1E
CSNK2A1
CTNNB1
CXXC4
DAAM1
DAB2
DVL3
DYNLT1
EPS8
FBXW7
FRAT1
HDHD2
HECW1
KLHL12
LRRK2
MLH3
MSH2
NCK2
NEDD4
PPM1A
PSMA3
RAC1
RB1
SIPA1
SMAD1
SMAD2
SMAD3
SMAD4
SMAD7
SMYD1
TRIM69
USP13
VANGL1
VANGL2
Entrez ID
1601
1855
HPRD ID
03139
03220
Ensembl ID
ENSG00000153071
ENSG00000107404
Uniprot IDs
A0A024R036
B2RAW0
P98082
O14640
PDB IDs
2LSW
6O5O
6OVF
6TTK
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?