PRKCD and CD34

Data Source:
HPRD (in vivo, in vitro)

		PRKCD	CD34
Description		protein kinase C delta	CD34 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Nuclear Matrix Azurophil Granule Lumen Endolysosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Apical Plasma Membrane Glomerular Endothelium Fenestra Intercellular Bridge Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Insulin Receptor Substrate Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Transcription Factor Binding Carbohydrate Binding Sulfate Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Signaling Receptor Activity Immunoglobulin Mediated Immune Response Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Termination Of Signal Transduction Platelet Activation Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Protein Binding Activation Of Protein Kinase Activity Positive Regulation Of Superoxide Anion Generation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Glial Cell Apoptotic Process Cellular Response To UV Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation Neutrophil Activation Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Neutrophil Degranulation Negative Regulation Of MAP Kinase Activity Regulation Of MRNA Stability Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Protein Stabilization Negative Regulation Of Filopodium Assembly Cell Chemotaxis Interferon-gamma-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Hydroperoxide Negative Regulation Of Platelet Aggregation Cellular Senescence Positive Regulation Of Phospholipid Scramblase Activity Cellular Response To Angiotensin Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Apoptotic Signaling Pathway	Tissue Homeostasis Endothelial Cell Proliferation Glomerular Filtration Endothelium Development Cell-matrix Adhesion Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Hemopoiesis Negative Regulation Of Blood Coagulation Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Mesangial Cell-matrix Adhesion Paracrine Signaling Positive Regulation Of Odontogenesis Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Cell Motility Regulation Of Immune Response Leukocyte Migration Transdifferentiation Vascular Wound Healing Hematopoietic Stem Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Extracellular Exosome Assembly Glomerular Endothelium Development Stem Cell Proliferation Metanephric Glomerular Mesangial Cell Differentiation Cell-cell Adhesion Negative Regulation Of Cellular Response To Heat Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Death Positive Regulation Of Vasculogenesis
Pathways		Apoptotic cleavage of cellular proteins Calmodulin induced events Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events HuR (ELAVL1) binds and stabilizes mRNA VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Interferon gamma signaling
Drugs		Tamoxifen 13-Acetylphorbol Ingenol mebutate Fostamatinib
Diseases
GWAS		Bipolar disorder ( 21926972) Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) ( 30120083) Ulcerative colitis ( 23128233) Waist circumference adjusted for body mass index ( 28552196)	Adventurousness ( 30643258) Age-related macular degeneration ( 23326517) Automobile speeding propensity ( 30643258) Drug experimentation measurement ( 30718321) Estimated glomerular filtration rate ( 31152163) Febrile seizures (MMR vaccine-related) ( 25344690) General risk tolerance (MTAG) ( 30643258) Heart rate ( 23583979) Refractive error ( 32231278) Resting heart rate ( 27798624 20639392) RR interval (heart rate) ( 30679814) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		120 interacting genes: ACTA1 ACTA2 ACTB ADAM9 ADCY7 ADD1 ADD2 ADRA2A ADRB2 AFAP1 AKT3 APP ART3 BDKRB2 C1QBP CD34 CDCP1 CHAT CNP CREBBP CYTH1 DAB2 DYNC1H1 EEF1A1 EGFR EIF2S1 ELAVL1 EP300 ESRRA FLI1 FSCN1 FYN GABRA1 GAP43 GNA12 GNA13 GNAZ GRK2 GRM5 GSK3A H1-1 H1-5 HABP4 HDAC5 HNRNPK HSP90AA1 HSPA4 IGF1R IKBKB IL6ST INSR IRS1 ITGA6 ITGB2 ITGB4 ITGB7 ITPR1 KCNJ1 KCNJ4 KLF5 LCK LMNB1 LMNB2 LYN MACF1 MAPK1 MAPK3 MAPT MBP MEP1B MS4A2 MUC1 NCF1 NCF4 NFE2L2 NOTCH1 NUMB OPRD1 PAK1 PDP1 PDP2 PDPK1 PEBP1 PIK3CA PIK3CB PLCB1 PLD2 PLSCR1 PLSCR3 PPARA PPM1A PPP1CA PPP2CA PPP2R5C PRKCZ PRKDC PTK2B PTPN22 PTPN6 PTPRA RAC1 RACK1 RAF1 RASGRP3 RIPK4 RUNX2 SDC4 SHC1 SPRY2 SQSTM1 SRC STAT1 STAT3 TAGLN TIAM1 TNFRSF1A VCP YWHAB YWHAG YWHAZ	4 interacting genes: AGR2 CHST4 CRKL PRKCD
Entrez ID		5580	947
HPRD ID		01501	00790
Ensembl ID		ENSG00000163932	ENSG00000174059
Uniprot IDs		A0A024R328 B4DFV1 Q05655	P28906
PDB IDs		1YRK 2YUU
Enriched GO Terms of Interacting Partners?
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