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PRKCD and KCNJ4
Data Source:
HPRD
(in vitro)
PRKCD
KCNJ4
Description
protein kinase C delta
potassium inwardly rectifying channel subfamily J member 4
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Plasma Membrane
Voltage-gated Potassium Channel Complex
Basolateral Plasma Membrane
Cytoplasmic Vesicle Membrane
Postsynaptic Membrane
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Calcium-independent Protein Kinase C Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Inward Rectifier Potassium Channel Activity
Protein Binding
PDZ Domain Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Cell Cycle
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Signaling Receptor Activity
Immunoglobulin Mediated Immune Response
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Termination Of Signal Transduction
Platelet Activation
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of MRNA Stability
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Potassium Ion Transport
Regulation Of Ion Transmembrane Transport
Cardiac Conduction
Potassium Ion Import Across Plasma Membrane
Pathways
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
Activation of G protein gated Potassium channels
Classical Kir channels
Phase 4 - resting membrane potential
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Tamoxifen
13-Acetylphorbol
Ingenol mebutate
Fostamatinib
Ranolazine
Miconazole
Carvedilol
Dronedarone
Diseases
GWAS
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
)
Automobile speeding propensity (
30643258
)
Chronotype (
30696823
)
Conotruncal heart defects (
24800985
)
TPE interval (resting) (
32386560
)
Interacting Genes
120 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
11 interacting genes:
CASK
DLG1
DLG2
DLG4
GNGT2
GPR35
IL16
KCNJ2
LIN7B
PRKCD
SNTA1
Entrez ID
5580
3761
HPRD ID
01501
02738
Ensembl ID
ENSG00000163932
ENSG00000168135
Uniprot IDs
A0A024R328
B4DFV1
Q05655
A0A024R1L8
P48050
Q58F07
PDB IDs
1YRK
2YUU
3GJ9
Enriched GO Terms of Interacting Partners
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