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PRKCD and NUMB
Data Source:
HPRD
(in vitro)
PRKCD
NUMB
Description
protein kinase C delta
NUMB endocytic adaptor protein
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Nucleus
Cytoplasm
Early Endosome
Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Endosome Membrane
Basolateral Plasma Membrane
Extrinsic Component Of Plasma Membrane
Clathrin-coated Vesicle
Apical Part Of Cell
Glutamatergic Synapse
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Calcium-independent Protein Kinase C Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Protein Binding
Beta-catenin Binding
Alpha-catenin Binding
Cadherin Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Cell Cycle
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Signaling Receptor Activity
Immunoglobulin Mediated Immune Response
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Termination Of Signal Transduction
Platelet Activation
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of MRNA Stability
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Axonogenesis
Lateral Ventricle Development
Neuroblast Division In Subventricular Zone
Positive Regulation Of Cell Migration
Adherens Junction Organization
Positive Regulation Of Neurogenesis
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Negative Regulation Of Protein Localization To Plasma Membrane
Pathways
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
Activated NOTCH1 Transmits Signal to the Nucleus
Recycling pathway of L1
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Drugs
Tamoxifen
13-Acetylphorbol
Ingenol mebutate
Fostamatinib
Diseases
GWAS
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
)
Bipolar disorder with mood-incongruent psychosis (
23092984
)
Coronary artery calcification (
17903303
)
Hemoglobin (
32888494
)
Macular thickness (
30535121
)
Multisite chronic pain (
31194737
)
Interacting Genes
120 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
37 interacting genes:
AP2A1
AP2A2
APP
DNAJC5
DPYSL2
EAF1
EGFR
EPS15
FBXO7
FRS3
IRS1
ITCH
ITGB2
ITGB3
ITGB5
L1CAM
LNX1
LNX2
MAPK8IP2
MDM2
NEDD4
NOTCH1
OLIG1
PALS1
PDZK1IP1
PRKCA
PRKCB
PRKCD
PRKCE
PRKCG
PRKCH
PRKCZ
PTEN
RPL3
SIAH1
SPANXN2
TERF2
Entrez ID
5580
8650
HPRD ID
01501
04767
Ensembl ID
ENSG00000163932
ENSG00000133961
Uniprot IDs
A0A024R328
B4DFV1
Q05655
A0A024R681
A0A024R684
A0A024R6C4
A0A024R6F4
P49757
PDB IDs
1YRK
2YUU
5NJJ
5NJK
Enriched GO Terms of Interacting Partners
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