BTBD2 and UBR1

Data Source:
HPRD (two hybrid)

		BTBD2	UBR1
Description		BTB domain containing 2	ubiquitin protein ligase E3 component n-recognin 1
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GO Annotations	Cellular Component	P-body Cytosol	Ubiquitin Ligase Complex Proteasome Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Leucine Binding
	Biological Process	Neurogenesis	Protein Ubiquitination Negative Regulation Of TOR Signaling Cellular Response To Leucine Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Johanson-Blizzard syndrome
GWAS		Mitochondrial DNA copy number (white blood cells) ( 30704525) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	MGMT methylation in smokers ( 26183928) Triglycerides ( 25961943)
Interacting Genes		35 interacting genes: BRD7 CCDC90B CCNC CDK2 CINP COPS6 CRMP1 CUL3 DPPA4 EEF1A1 ERG28 GAPDH GBP2 GDF9 IGSF21 KPNA2 MLH1 NGB NTAQ1 OSGIN1 PSMD5 PTN RBM48 SETDB1 SMAD1 SMAD2 TDP2 TGFBR1 TLE1 TOP1 TP53 TRIM5 UBR1 UNC119 ZNF512B	28 interacting genes: ANXA3 ARL15 ARL3 ARL4D BCL2L1 BTBD2 CDC42 CDC6 DLEU1 DNAJB11 FOS FTH1 GADD45A GSK3B LAMA4 LAMTOR3 NDUFA4L2 NTAN1 NTAQ1 NUDT3 PTPRS SERPINB9 SPRY2 TAC3 TP53I3 UBE2A UBE2B UBE2D2
Entrez ID		55643	197131
HPRD ID		12252	09342
Ensembl ID		ENSG00000133243	ENSG00000159459
Uniprot IDs		Q9BX70	Q8IWV7
PDB IDs		3NO8	3NY1 5TDC
Enriched GO Terms of Interacting Partners?
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