LEP and HSF2BP

Data Source:
BioGRID (two hybrid)

		LEP	HSF2BP
Description		leptin	heat shock transcription factor 2 binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Chromosome Cytosol
	Molecular Function	DNA Binding Hormone Activity Protein Binding Peptide Hormone Receptor Binding Leptin Receptor Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Ovulation From Ovarian Follicle Response To Hypoxia Placenta Development Positive Regulation Of Protein Phosphorylation Regulation Of Endothelial Cell Proliferation Response To Dietary Excess Cardiac Muscle Hypertrophy Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Lipid Metabolic Process Fatty Acid Beta-oxidation Phagocytosis Tyrosine Phosphorylation Of STAT Protein Female Pregnancy Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Determination Of Adult Lifespan Adult Feeding Behavior Negative Regulation Of Autophagy Negative Regulation Of Lipid Storage Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Activity Sexual Reproduction Central Nervous System Neuron Development Insulin Secretion T Cell Differentiation Regulation Of Intestinal Cholesterol Absorption Positive Regulation Of TOR Signaling Negative Regulation Of Appetite Prostaglandin Secretion Response To Estradiol Interleukin-6 Production Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Proliferation Response To Insulin Cellular Response To Insulin Stimulus Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Intracellular Signal Transduction Bone Mineralization Involved In Bone Maturation Aorta Development Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Import Into Nucleus Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Response To Ethanol Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Negative Regulation Of Glucose Import Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Insulin Receptor Signaling Pathway Regulation Of Bone Remodeling Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Intestinal Absorption Leukocyte Tethering Or Rolling Regulation Of Nitric-oxide Synthase Activity Elastin Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Regulation Of Brown Fat Cell Differentiation Bone Growth Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Fat Cell Apoptotic Process Activation Of Protein Kinase C Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation	Transcription By RNA Polymerase II Male Meiosis I Spermatogenesis Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Signaling by Leptin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS		BMI at 1.5 years old ( 31575865) BMI at 8 months old ( 31575865) Body size at age 10 ( 32376654) circulating leptin levels ( 32917775 26833098) circulating leptin levels adjusted for BMI ( 32917775 26833098) High density lipoprotein cholesterol levels ( 29403010) Type 2 diabetes ( 26818947 23945395 32499647)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Eosinophilic esophagitis ( 25017104) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Plasma anti-thyroid peroxidase levels ( 29678681) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) Systolic blood pressure ( 30578418)
Interacting Genes		10 interacting genes: A2M CLU CRP GHRL HK3 HSF2BP LEPR PRKAA2 SIGLEC6 UCN	293 interacting genes: ABI2 ABLIM1 ACTN3 ADD1 ANAPC16 ANKRD55 ANKS1B ARHGAP45 ARHGEF3 ARHGEF4 ARHGEF5 ARHGEF6 ATXN7L2 BARD1 BAX BAZ2B BCAS2 BEND7 BEX2 BLK BMI1 BYSL C10orf88 C18orf54 C1orf35 C1orf94 C2CD6 C4orf46 C5orf49 C7orf31 C9orf24 CAMSAP3 CARD9 CASS4 CBX8 CBY2 CCDC113 CCDC116 CCDC120 CCDC13 CCDC130 CCDC146 CCDC185 CCDC187 CCDC198 CCDC33 CCHCR1 CCSER1 CDC37 CDC73 CDCA7L CDR2L CDYL2 CEP55 CEP57 CKS1B CLIP4 CNNM1 CNNM3 CNOT2 COIL CTSZ CTTNBP2 CTTNBP2NL CWF19L2 DALRD3 DCDC2B DEFB112 DMAP1 DMRT3 DOCK8 DPF2 DUSP13 EAF1 EIF3D ELOA2 EMD ENKD1 EPHB3 EPM2AIP1 FAM107A FAM110A FAM110B FAM124B FAM161B FAM214B FAM228A FAM90A1 FBXO44 FHL2 FHL3 FLYWCH1 FUT9 GAS2L2 GAS8 GCM2 GEM GGN GNL3L GOLGA1 GPANK1 GPATCH2L GPBP1 GPKOW GPSM3 H2AW HASPIN HCK HDAC4 HEXIM2 HEY2 HNRNPH2 HOMEZ HOXB5 HOXC8 HSF2 IER2 IL16 INO80B INPP5J INSYN2A IPMK IQCC ITGB3BP JRK KANK2 KAT5 KIAA0408 KIF24 KIF5B KIF9 KIFC3 KLF4 L3MBTL2 L3MBTL3 L3MBTL4 LAGE3 LEP LGALS4 LMO4 LNX1 LRRC29 LRRC56 LRRN4 LUZP4 MAGED1 MAGOHB MARCHF7 MEF2A MFAP1 MISP MKRN3 MVB12A MYOZ3 NAB2 NCK2 NFIL3 NHSL2 NME4 NPPA NSMF NTAQ1 NUDT10 NXF1 ODF3B ODF3L2 OPTN P2RX7 PAK6 PAPSS2 PARD6B PDLIM7 PICK1 PKD2 PKN1 PKP1 PLB1 PLEKHA2 PLEKHA7 PNMA5 POGZ POLDIP3 POMC PPM1K PPP1R18 PPP1R32 PRPF18 PRPF3 PRPF31 PRR5L PSMA1 PSTPIP1 RAB11FIP2 RAB36 RAB3IL1 RAD51D RALY RBM17 RBM41 RBM48 RCOR3 REXO4 RIBC1 RIN1 RNF135 RNF169 ROBO3 RPS28 RTP5 SAMD4A SAPCD1 SART1 SAXO1 SCNM1 SDCBP SELENOV SEMA3B SEMA4C SEPTIN1 SEPTIN9 SETDB1 SH2D4A SHFL SHISA6 SIRPA SLAIN1 SLC6A1 SMARCB1 SMARCD1 SMG9 SNAPC1 SNW1 SNX18 SNX21 SPATA22 SPEG SPG7 SPRED1 SPRY1 SYCE1L SYNGAP1 TAB2 TAGAP TASOR2 TBC1D1 TBC1D30 TCEA2 TCF19 TEPSIN TFIP11 THAP6 TMEFF2 TMSB4X TNS4 TOX2 TP53BP2 TRAF5 TRARG1 TSEN15 TSGA10IP TSHZ3 TTC23 TTC9C TULP3 UBE2I UPF2 UPRT USP20 VEZF1 VHL VPS72 WASF1 WASHC1 WDR25 ZBTB16 ZBTB42 ZC2HC1C ZCWPW2 ZFC3H1 ZGPAT ZNF185 ZNF250 ZNF417 ZNF511 ZNF564 ZNF581 ZNF587 ZNF648 ZNF688 ZNF774 ZNF835 ZNF84 ZNF844
Entrez ID		3952	11077
HPRD ID		01249	05186
Ensembl ID		ENSG00000174697	ENSG00000160207
Uniprot IDs		A4D0Y8 P41159	O75031 Q6IAT7
PDB IDs		1AX8
Enriched GO Terms of Interacting Partners?
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