PIDD1 and HSD17B14

Data Source:
BioGRID (two hybrid)

		PIDD1	HSD17B14
Description		p53-induced death domain protein 1	hydroxysteroid 17-beta dehydrogenase 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol	Cytosol
	Molecular Function	Endopeptidase Activity Death Receptor Binding Protein Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity	Estrogen Biosynthetic Process Steroid Catabolic Process
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases	Estrogen biosynthesis
Drugs
Diseases
GWAS		Breast cancer ( 29059683)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		15 interacting genes: AFP CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ SOX8 TEAD3	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		55367	51171
HPRD ID		11284	16801
Ensembl ID		ENSG00000177595	ENSG00000087076
Uniprot IDs		Q9HB75	A0A140VJH8 Q9BPX1
PDB IDs		2OF5	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK
Enriched GO Terms of Interacting Partners?
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