PIDD1 and TEAD3

Data Source:
BioGRID (two hybrid)

		PIDD1	TEAD3
Description		p53-induced death domain protein 1	TEA domain transcription factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol	Chromatin Nucleoplasm Transcription Regulator Complex
	Molecular Function	Endopeptidase Activity Death Receptor Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Female Pregnancy Hippo Signaling Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Asymmetric Neuroblast Division
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs
Diseases
GWAS		Breast cancer ( 29059683)	Birth weight ( 31043758) Colorectal cancer or advanced adenoma ( 30510241) Offspring birth weight ( 31043758)
Interacting Genes		15 interacting genes: AFP CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ SOX8 TEAD3	15 interacting genes: AP4S1 CTBP2 E2F1 E2F3 KIFC2 MYH7 PHB2 PIDD1 SUMO2 VGLL1 VGLL2 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		55367	7005
HPRD ID		11284	04411
Ensembl ID		ENSG00000177595	ENSG00000007866
Uniprot IDs		Q9HB75	Q99594
PDB IDs		2OF5	5EMW
Enriched GO Terms of Interacting Partners?
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