HSD17B14 and BRIP1

Data Source:
BioGRID (two hybrid)

		HSD17B14	BRIP1
Description		hydroxysteroid 17-beta dehydrogenase 14	BRCA1 interacting protein C-terminal helicase 1
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GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity	DNA Binding DNA Helicase Activity Chromatin Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Estrogen Biosynthetic Process Steroid Catabolic Process	DNA Damage Checkpoint DNA Replication Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II Spermatogonial Cell Division Spermatid Development Negative Regulation Of Cell Population Proliferation Response To Toxic Substance Negative Regulation Of Gene Expression Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination DNA Duplex Unwinding Chiasma Assembly Cellular Response To Vitamin Cellular Response To Hypoxia Seminiferous Tubule Development Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Angiotensin Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Estrogen biosynthesis	Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases			Fanconi anemia
GWAS		Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B	10 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HSD17B14 RPA1 SIRT1 TOPBP1
Entrez ID		51171	83990
HPRD ID		16801	05797
Ensembl ID		ENSG00000087076	ENSG00000136492
Uniprot IDs		A0A140VJH8 Q9BPX1	Q9BX63
PDB IDs		1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK	1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?
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