HSD17B14 and CA8

Data Source:
BioGRID (two hybrid)

		HSD17B14	CA8
Description		hydroxysteroid 17-beta dehydrogenase 14	carbonic anhydrase 8
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GO Annotations	Cellular Component	Cytosol	Cytoplasm
	Molecular Function	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	Estrogen Biosynthetic Process Steroid Catabolic Process	One-carbon Metabolic Process Phosphatidylinositol-mediated Signaling
Pathways		Estrogen biosynthesis
Drugs			Zonisamide
Diseases
GWAS		Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)	Adult body size ( 32376654) Blood protein levels ( 30072576) Cardiac hypertrophy ( 21348951) Free thyroxine concentration ( 30367059) Height ( 31562340) Hemoglobin ( 32888494) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 27182965) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to amphetamines ( 22952603) Schizophrenia ( 28991256 25056061 29483656 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B	14 interacting genes: CRX GGA2 HSD17B14 INTS7 ITPR1 KLHL8 LMNB2 LNX1 LRCH4 MAGED1 RAB34 SPDL1 STAT3 TBX3
Entrez ID		51171	767
HPRD ID		16801	00266
Ensembl ID		ENSG00000087076	ENSG00000178538
Uniprot IDs		A0A140VJH8 Q9BPX1	P35219
PDB IDs		1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK	2W2J
Enriched GO Terms of Interacting Partners?
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