HSD17B14 and OTUD3

Data Source:
BioGRID (two hybrid)

		HSD17B14	OTUD3
Description		hydroxysteroid 17-beta dehydrogenase 14	OTU deubiquitinase 3
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GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol
	Molecular Function	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Estrogen Biosynthetic Process Steroid Catabolic Process	Protein Deubiquitination Protein Phosphopantetheinylation Protein K11-linked Deubiquitination Protein K6-linked Deubiquitination Protein Stabilization Negative Regulation Of Protein Kinase B Signaling Protein K48-linked Deubiquitination Protein K27-linked Deubiquitination
Pathways		Estrogen biosynthesis	Ovarian tumor domain proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)	group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 19915572 28067908 20228798 20228799 19122664 23511034)
Interacting Genes		24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B	4 interacting genes: HSD17B14 HSPA5 PTEN UBC
Entrez ID		51171	23252
HPRD ID		16801	19417
Ensembl ID		ENSG00000087076	ENSG00000169914
Uniprot IDs		A0A140VJH8 Q9BPX1	Q5T2D3
PDB IDs		1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK	4BOU
Enriched GO Terms of Interacting Partners?
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