PIDD1 and KHDC4

Data Source:
BioGRID (two hybrid)

		PIDD1	KHDC4
Description		p53-induced death domain protein 1	KH domain containing 4, pre-mRNA splicing factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm
	Molecular Function	Endopeptidase Activity Death Receptor Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity	MRNA Splice Site Selection
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Breast cancer ( 29059683)
Interacting Genes		15 interacting genes: AFP CASP2 CCDC85B CRADD EFEMP2 FADD HSD17B14 KHDC4 MADD MAFG MDFI MTNR1B POGZ SOX8 TEAD3	21 interacting genes: BANP C14orf119 DNAJC5 KCNIP3 MAGEA12 NRF1 NUTF2 PIDD1 PRKAB2 PRR13 PSMB1 PUF60 QRICH1 RBM23 RBM39 RHOXF2 SAT1 SPANXN2 U2AF2 ZDHHC17 ZRSR2
Entrez ID		55367	22889
HPRD ID		11284	17198
Ensembl ID		ENSG00000177595	ENSG00000132680
Uniprot IDs		Q9HB75	Q7Z7F0
PDB IDs		2OF5	2YQR
Enriched GO Terms of Interacting Partners?
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