SLFN12 and JMJD6

Data Source:
BioGRID (two hybrid)

		SLFN12	JMJD6
Description		schlafen family member 12	jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Ribonucleoprotein Complex
	Molecular Function	Protein Binding	RNA Binding Single-stranded RNA Binding Iron Ion Binding Protein Binding Demethylase Activity Histone Demethylase Activity Histone Demethylase Activity (H3-R2 Specific) Histone Demethylase Activity (H4-R3 Specific) Oxidative RNA Demethylase Activity Signaling Receptor Activity Identical Protein Binding Peptidyl-lysine 5-dioxygenase Activity P-TEFb Complex Binding Transcription Regulator Activator Activity
	Biological Process		Kidney Development Sprouting Angiogenesis MRNA Processing Protein Demethylation Cell Surface Receptor Signaling Pathway Heart Development RNA Splicing Protein Phosphopantetheinylation Peptidyl-lysine Hydroxylation To 5-hydroxy-L-lysine Lung Development T Cell Differentiation In Thymus Oxidative RNA Demethylation Macrophage Activation Recognition Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Erythrocyte Development Protein Homooligomerization Retina Development In Camera-type Eye Histone H3-R2 Demethylation Histone H4-R3 Demethylation
Pathways			HDMs demethylate histones
Drugs
Diseases
GWAS			Neutrophil count ( 32888494) Retinal arteriolar caliber ( 23776548)
Interacting Genes		4 interacting genes: JMJD6 SUV39H1 TRIM55 TRIM63	27 interacting genes: AEBP2 ANKEF1 C17orf97 CCNL1 CENPL CXCL14 DIP2A FGD5 FRMD6 GNA14 H2BC11 H3C1 H4C1 HMGXB4 LARP7 NAA50 NFIX NHP2 PRPF38A PSMC1 RSPO2 SLFN12 SLU7 STAC3 TAF1A U2AF1 ZNF451
Entrez ID		55106	23210
HPRD ID		08543	05371
Ensembl ID		ENSG00000172123	ENSG00000070495
Uniprot IDs		Q8IYM2	Q6NYC1
PDB IDs			3K2O 3LD8 3LDB 6BNH 6GDY 6MEV
Enriched GO Terms of Interacting Partners?
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