ESRP1 and MED25

Data Source:
BioGRID (two hybrid)

		ESRP1	MED25
Description		epithelial splicing regulatory protein 1	mediator complex subunit 25
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Body Ribonucleoprotein Complex	Nucleoplasm Transcription Regulator Complex Mediator Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding
	Biological Process	MRNA Processing RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Inner Ear Auditory Receptor Cell Fate Specification Regulation Of RNA Splicing	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Mediator Complex Assembly
Pathways		Signaling by BRAF and RAF fusions FGFR2 alternative splicing	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Abstraction and mental flexibility ( 31596458) Urate levels ( 31578528)	Blood trace element (Se levels) ( 23720494)
Interacting Genes		45 interacting genes: ARID5A ATXN1 DAZAP2 KLHDC7B KRTAP19-5 MED25 MIR106A MIR106B MIR128-2 MIR138-1 MIR138-2 MIR141 MIR155 MIR15B MIR19B1 MIR19B2 MIR200A MIR200C MIR20B MIR21 MIR222 MIR25 MIR29C MIR34A MIR34B MIR363 MIR7-1 MIR9-1 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7F2 MIRLET7G MIRLET7I OXER1 PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS2	37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2
Entrez ID		54845	81857
HPRD ID		07881	14380
Ensembl ID		ENSG00000104413	ENSG00000104973
Uniprot IDs		A0A2U3TZN9 Q6NXG1	Q71SY5
PDB IDs		2DHA 2RVJ	2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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