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RNF111 and UBE2M
Data Source:
BioGRID
(two hybrid)
RNF111
UBE2M
Description
ring finger protein 111
ubiquitin conjugating enzyme E2 M
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Protein-containing Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Protein Binding
SUMO Polymer Binding
SMAD Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
NEDD8 Transferase Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Pattern Specification Process
Protein Ubiquitination
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Global Genome Nucleotide-excision Repair
Cellular Protein Modification Process
Protein Phosphopantetheinylation
Positive Regulation Of Neuron Apoptotic Process
Post-translational Protein Modification
Protein Neddylation
Pathways
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Formation of Incision Complex in GG-NER
Antigen processing: Ubiquitination & Proteasome degradation
TGF-beta receptor signaling activates SMADs
Dectin-1 mediated noncanonical NF-kB signaling
NIK-->noncanonical NF-kB signaling
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Asperger disorder (
21182207
)
Atopic dermatitis (
25865352
)
Cerebrospinal fluid AB1-42 levels (
28247064
)
Metabolite levels (
22916037
)
Social communication problems (
24047820
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
54 interacting genes:
ACTN3
ANAPC11
AP2M1
AXIN1
CREB1
CREBBP
CSNK2A1
CTBP1
DTX3L
EDARADD
KRTAP1-1
KRTAP5-9
LCE4A
LRSAM1
MARCHF7
MDFI
MVP
NBPF19
NOTCH2NLA
PAX6
PHF7
PML
PSME3
PTPN3
SDCBP2
SMAD3
SMAD6
SMAD7
SMURF2
SUMO1
SUMO2
SUMO3
TRAF5
TRIM21
TRIM8
TSG101
TSPYL1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2M
UBE2N
UBE2Q2
UBE2V1
UBE2W
VAPB
30 interacting genes:
APP
CAND1
CBL
CPNE1
CPNE2
CPNE4
CUL1
CUL7
DCUN1D1
DCUN1D2
DCUN1D3
DCUN1D4
DCUN1D5
FBXO7
HSPA4
ITCH
MARCHF7
NEDD4
NEDD8
PINK1
PRKN
RBX1
RNF111
RNF7
SENP8
SMURF1
TERF1
TP53
UBA1
UBA3
Entrez ID
54778
9040
HPRD ID
09318
04414
Ensembl ID
ENSG00000157450
ENSG00000130725
Uniprot IDs
A0A024R5T5
Q6ZNA4
A0A024R4T4
P61081
PDB IDs
2KIZ
5LG0
5LG7
1TT5
1Y8X
2NVU
3TDU
3TDZ
4GAO
4P5O
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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