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RNF111 and SMAD7
Data Source:
HPRD
(in vivo, in vitro)
RNF111
SMAD7
Description
ring finger protein 111
SMAD family member 7
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Protein-containing Complex
Chromatin
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Plasma Membrane
Adherens Junction
Catenin Complex
Protein-containing Complex
Heteromeric SMAD Protein Complex
Molecular Function
Protein Binding
SUMO Polymer Binding
SMAD Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
DNA Binding
Protein Binding
Collagen Binding
Beta-catenin Binding
Ubiquitin Protein Ligase Binding
Type I Transforming Growth Factor Beta Receptor Binding
Metal Ion Binding
Activin Binding
I-SMAD Binding
Transcription Regulator Inhibitor Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Pattern Specification Process
Protein Ubiquitination
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Global Genome Nucleotide-excision Repair
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Negative Regulation Of T Cell Cytokine Production
Regulation Of Transcription By RNA Polymerase II
Transforming Growth Factor Beta Receptor Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Transcription By Competitive Promoter Binding
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cell-cell Adhesion
Cell Differentiation
Negative Regulation Of Ossification
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Activin Receptor Signaling Pathway
Negative Regulation Of Peptidyl-serine Phosphorylation
Adherens Junction Assembly
Response To Laminar Fluid Shear Stress
Cellular Protein-containing Complex Localization
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Transcription By RNA Polymerase II
Artery Morphogenesis
Protein Stabilization
Negative Regulation Of Ubiquitin-protein Transferase Activity
Ventricular Cardiac Muscle Tissue Morphogenesis
Regulation Of Cardiac Muscle Contraction
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Chondrocyte Proliferation
Positive Regulation Of Chondrocyte Hypertrophy
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of T-helper 17 Type Immune Response
Negative Regulation Of T-helper 17 Cell Differentiation
Pathways
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Formation of Incision Complex in GG-NER
Antigen processing: Ubiquitination & Proteasome degradation
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
UCH proteinases
Ub-specific processing proteases
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Asperger disorder (
21182207
)
Atopic dermatitis (
25865352
)
Cerebrospinal fluid AB1-42 levels (
28247064
)
Metabolite levels (
22916037
)
Social communication problems (
24047820
)
Asthma (
32296059
)
Atrial fibrillation (
30061737
29892015
)
Colorectal cancer (
25990418
18372901
18372905
30529582
21761138
17934461
26151821
29228715
30104761
24836286
29471430
24448986
31826910
23266556
)
Colorectal cancer or advanced adenoma (
30510241
)
Coronary artery disease (
33020668
)
Creatinine levels (
29403010
)
Dental caries (
23064961
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Estimated glomerular filtration rate (
31152163
31015462
30604766
)
Glomerular filtration rate (
29403010
)
Heel bone mineral density (
30598549
)
Hematocrit (
32888494
27863252
)
Hemoglobin (
32888494
)
Hemoglobin concentration (
27863252
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
23128233
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Parental longevity (at least one long-lived parent) (
27816938
)
Red blood cell count (
32888494
27863252
)
Interacting Genes
54 interacting genes:
ACTN3
ANAPC11
AP2M1
AXIN1
CREB1
CREBBP
CSNK2A1
CTBP1
DTX3L
EDARADD
KRTAP1-1
KRTAP5-9
LCE4A
LRSAM1
MARCHF7
MDFI
MVP
NBPF19
NOTCH2NLA
PAX6
PHF7
PML
PSME3
PTPN3
SDCBP2
SMAD3
SMAD6
SMAD7
SMURF2
SUMO1
SUMO2
SUMO3
TRAF5
TRIM21
TRIM8
TSG101
TSPYL1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2I
UBE2K
UBE2M
UBE2N
UBE2Q2
UBE2V1
UBE2W
VAPB
59 interacting genes:
ACVR1B
AKT1
ASH1L
AXIN1
AXIN2
BMPR1B
CBL
CTNNB1
CXXC5
DVL1
EP300
ERBIN
HAT1
HEYL
KDM2A
MAP2K3
MAP2K6
MAP3K7
MAPK14
MBD1
MRTFB
MYOD1
NEDD4L
OTUD1
PARD3
PIAS1
PIAS4
RLIM
RNF111
SASH3
SETD7
SIRT1
SMAD2
SMAD3
SMAD4
SMAD6
SMURF1
SMURF2
SOX13
SOX5
SOX7
STAMBP
STAMBPL1
STRAP
TAB1
TGFB1I1
TGFBR1
TGFBR2
TTF1
TTF2
UBE2L3
UCHL5
WWP2
XRCC6
YAP1
ZBTB11
ZBTB44
ZEB1
ZNF107
Entrez ID
54778
4092
HPRD ID
09318
04241
Ensembl ID
ENSG00000157450
ENSG00000101665
Uniprot IDs
A0A024R5T5
Q6ZNA4
B3KYA8
O15105
PDB IDs
2KIZ
5LG0
5LG7
2DJY
2KXQ
2LTV
2LTW
2LTX
2LTY
2LTZ
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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