GINS4 and CDC45

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GINS4	CDC45
Description		GINS complex subunit 4	cell division cycle 45
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GO Annotations	Cellular Component	GINS Complex Nucleoplasm Cytoplasm CMG Complex	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body
	Molecular Function	Protein Binding	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly
Pathways		Unwinding of DNA Unwinding of DNA	Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		17 interacting genes: BIN3 CDC45 CTNNBIP1 DMAP1 GINS1 GINS2 GINS3 KIF16B LHX8 MCM2 PBX4 POLA1 POLD1 POLE PPP1R13B SIK1 SIK1B	25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1
Entrez ID		84296	8318
HPRD ID		11583	09145
Ensembl ID		ENSG00000147536	ENSG00000093009
Uniprot IDs		Q9BRT9	O75419
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY	5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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