GINS4 and CTNNBIP1

Data Source:
BioGRID (two hybrid)

		GINS4	CTNNBIP1
Description		GINS complex subunit 4	catenin beta interacting protein 1
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GO Annotations	Cellular Component	GINS Complex Nucleoplasm Cytoplasm CMG Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Beta-catenin Destruction Complex
	Molecular Function	Protein Binding	Protein Binding Beta-catenin Binding Armadillo Repeat Domain Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication	Branching Involved In Ureteric Bud Morphogenesis Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Anterior/posterior Pattern Specification Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Monocyte Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Mesenchymal Cell Proliferation
Pathways		Unwinding of DNA Unwinding of DNA	Deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS			Platelet distribution width ( 32888494) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		17 interacting genes: BIN3 CDC45 CTNNBIP1 DMAP1 GINS1 GINS2 GINS3 KIF16B LHX8 MCM2 PBX4 POLA1 POLD1 POLE PPP1R13B SIK1 SIK1B	19 interacting genes: BEND5 CTNNA2 CTNNB1 EMD GINS4 INCA1 JUP KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP5-9 MSS51 NBPF19 NOTCH2NLA P4HA3 REL SPATA24 TCF7L2 USHBP1
Entrez ID		84296	56998
HPRD ID		11583	09677
Ensembl ID		ENSG00000147536	ENSG00000178585
Uniprot IDs		Q9BRT9	A0A024R4D7 Q9NSA3
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY	1LUJ 1M1E 1T08
Enriched GO Terms of Interacting Partners?
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