GINS4 and SIK1

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		GINS4	SIK1
Description		GINS complex subunit 4	salt inducible kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	GINS Complex Nucleoplasm Cytoplasm CMG Complex	Nucleus Cytoplasm
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding 14-3-3 Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication	Regulation Of Sodium Ion Transport Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Myotube Differentiation Negative Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction Cellular Response To Glucose Starvation Entrainment Of Circadian Clock By Photoperiod Regulation Of Cell Differentiation Negative Regulation Of Gluconeogenesis Protein Autophosphorylation Rhythmic Process Cardiac Muscle Cell Differentiation Positive Regulation Of Anoikis
Pathways		Unwinding of DNA Unwinding of DNA	Circadian Clock
Drugs			Dabrafenib Fostamatinib
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer disease and age of onset ( 26830138) Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 28135244 27841878 28739976 27618452) Red vs. brown/black hair color ( 30531825) Systolic blood pressure ( 27841878 28739976 27618452)
Interacting Genes		17 interacting genes: BIN3 CDC45 CTNNBIP1 DMAP1 GINS1 GINS2 GINS3 KIF16B LHX8 MCM2 PBX4 POLA1 POLD1 POLE PPP1R13B SIK1 SIK1B	13 interacting genes: CRTC2 GINS4 HDAC5 MAPT MCM2 NMNAT1 PRKACA RNF2 RPL3 STK11 SUPT5H VAPA YWHAZ
Entrez ID		84296	150094
HPRD ID		11583	09301
Ensembl ID		ENSG00000147536	ENSG00000142178
Uniprot IDs		Q9BRT9	P57059
PDB IDs		2E9X 2EHO 2Q9Q 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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