EXOSC10 and UPF2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EXOSC10	UPF2
Description		exosome component 10	UPF2 regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Transcriptionally Active Chromatin	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding 3'-5'-exoribonuclease Activity RNA Binding Single-stranded RNA Binding Exoribonuclease Activity Protein Binding Telomerase RNA Binding	RNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)	Diverticular disease ( 30177863)
Interacting Genes		37 interacting genes: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 XRN1 XRN2	76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		5394	26019
HPRD ID		16180	10405
Ensembl ID		ENSG00000171824	ENSG00000151461
Uniprot IDs		Q01780	Q9HAU5
PDB IDs		2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R	1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
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