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UPF2 and EIF4G1
Data Source:
HPRD
(in vivo)
UPF2
EIF4G1
Description
UPF2 regulator of nonsense mediated mRNA decay
eukaryotic translation initiation factor 4 gamma 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Polysome
Exon-exon Junction Complex
Cytoplasmic Ribonucleoprotein Granule
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Cytosol
Polysome
Cytoplasmic Stress Granule
Membrane
Eukaryotic Translation Initiation Factor 4F Complex
Molecular Function
RNA Binding
Protein Binding
Telomeric DNA Binding
RNA Binding
MRNA Binding
Translation Initiation Factor Activity
Protein Binding
ATP Binding
Translation Factor Activity, RNA Binding
Eukaryotic Initiation Factor 4E Binding
Translation Initiation Factor Binding
Identical Protein Binding
Molecular Adaptor Activity
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Liver Development
MRNA Export From Nucleus
Animal Organ Regeneration
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Behavioral Fear Response
Cap-dependent Translational Initiation
Translation
Translational Initiation
Regulation Of Translational Initiation
Negative Regulation Of Autophagy
Negative Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Cell Death
Viral Process
Positive Regulation Of Cell Growth
Cellular Response To Nutrient Levels
Positive Regulation Of Cellular Protein Metabolic Process
Developmental Process
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Macromolecule Biosynthetic Process
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Regulation Of MRNA Stability
Positive Regulation Of Neuron Differentiation
Regulation Of Gene Silencing By MiRNA
Regulation Of Cellular Response To Stress
Energy Homeostasis
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Neuron Death
Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly
Regulation Of Presynapse Assembly
Positive Regulation Of MRNA Cap Binding
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Regulation Of Polysome Binding
Pathways
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
ISG15 antiviral mechanism
L13a-mediated translational silencing of Ceruloplasmin expression
mTORC1-mediated signalling
Deadenylation of mRNA
AUF1 (hnRNP D0) binds and destabilizes mRNA
Translation initiation complex formation
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Diverticular disease (
30177863
)
Menarche (age at onset) (
25231870
)
Red blood cell count (
32888494
)
Interacting Genes
76 interacting genes:
ABCF2
AGPAT1
AKTIP
ART4
ATP1B3
BLM
CALR
CENPU
CIZ1
COMTD1
CYBA
DCP1B
DCP2
DPF2
E4F1
EIF1
EIF4A1
EIF4G1
ENO1
EXOSC1
EXOSC10
EXOSC4
EXOSC6
EXOSC8
GADD45GIP1
HBZ
HMGA1
HS3ST3A1
HSF2BP
ITGB1
KRT18
LDHA
LSM1
MAP1A
MAP1LC3B
MIF
MRPL40
MTERF3
MTREX
MYB
NDUFA7
NOB1
NOMO1
NOP53
PHB2
PITX1
PUF60
RNPS1
RPL13
RPL5
RPL8
RPS15
RPS25
RPS6
RPS7
RRP7A
RSRC2
SERBP1
SERF2
SMG1
SUMO3
TK1
TNNI2
TOP3B
TUBB2A
TYMS
UPF1
UPF3B
WNK1
XRN1
XRN2
ZBTB48
ZFP36
ZGPAT
ZNF408
ZNF44
40 interacting genes:
A1CF
ANXA5
ATPAF2
CCDC57
CDKN2D
CENPU
CIB1
CTBP2
DTX2
EIF1
EIF3A
EIF3B
EIF3I
EIF4A1
EIF4A2
EIF4E
EIF5
ENKD1
FXR2
GK
HSPB1
HTRA2
KRT31
KRT34
MKNK1
MKNK2
NCBP1
NCBP2
NTAQ1
PABPC1
PAK2
PDCD4
PEF1
SMARCD1
SRPK2
SUMO2
TRAF2
UBE3A
UPF2
ZFYVE9
Entrez ID
26019
1981
HPRD ID
10405
06774
Ensembl ID
ENSG00000151461
ENSG00000114867
Uniprot IDs
Q9HAU5
B2RU06
B2RU10
B4DSI9
O95065
Q04637
Q96I65
PDB IDs
1UW4
2WJV
4CEK
4CEM
1LJ2
1UG3
2W97
4AZA
4F02
5EHC
5EI3
5EIR
5T46
6ZMW
Enriched GO Terms of Interacting Partners
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