UPF2 and ART4

Data Source:
BioGRID (two hybrid)

		UPF2	ART4
Description		UPF2 regulator of nonsense mediated mRNA decay	ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Extracellular Region Plasma Membrane Membrane Anchored Component Of Membrane
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity NAD+-protein-arginine ADP-ribosyltransferase Activity NADP+-protein-arginine ADP-ribosyltransferase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration	Protein ADP-ribosylation Arginine Metabolic Process Peptidyl-arginine ADP-ribosylation
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Diverticular disease ( 30177863)	Blood protein levels ( 29875488) Hand grip strength ( 29691431)
Interacting Genes		76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	2 interacting genes: APP UPF2
Entrez ID		26019	420
HPRD ID		10405	04364
Ensembl ID		ENSG00000151461	ENSG00000111339
Uniprot IDs		Q9HAU5	Q93070
PDB IDs		1UW4 2WJV 4CEK 4CEM
Enriched GO Terms of Interacting Partners?
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