UPF2 and DPF2

Data Source:
BioGRID (two hybrid)

		UPF2	DPF2
Description		UPF2 regulator of nonsense mediated mRNA decay	double PHD fingers 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Exon-exon Junction Complex Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm	Chromatin Nucleus Nucleoplasm Centrosome Cytosol Intracellular Membrane-bounded Organelle NBAF Complex
	Molecular Function	RNA Binding Protein Binding Telomeric DNA Binding	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Histone Binding Metal Ion Binding H3K9me3 Modified Histone Binding Lysine-acetylated Histone Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Animal Organ Regeneration	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Apoptotic Process Nervous System Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway Negative Regulation Of Myeloid Progenitor Cell Differentiation
Pathways		Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Diverticular disease ( 30177863)	Acne (severe) ( 24927181) Mean spheric corpuscular volume ( 32888494) Urate levels ( 31578528)
Interacting Genes		76 interacting genes: ABCF2 AGPAT1 AKTIP ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MTREX MYB NDUFA7 NOB1 NOMO1 NOP53 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44	20 interacting genes: FHL2 GOLGA6L9 H3-4 H3C1 H4C1 HSF2BP LDOC1 LNX1 MEOX2 NFKB2 PICK1 REL RELB RINT1 RUBCN TTC23L TXNDC12 UPF2 ZNF212 ZNF655
Entrez ID		26019	5977
HPRD ID		10405	03394
Ensembl ID		ENSG00000151461	ENSG00000133884
Uniprot IDs		Q9HAU5	A0A024R582 J3KMZ8 Q92785
PDB IDs		1UW4 2WJV 4CEK 4CEM	3IUF 5B79 5VDC 6LTH 6LTJ
Enriched GO Terms of Interacting Partners?
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