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EXOSC9 and PALS2
Data Source:
HPRD
(in vivo)
EXOSC9
PALS2
Description
exosome component 9
protein associated with LIN7 2, MAGUK family member
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nuclear Chromosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Extracellular Exosome
Plasma Membrane
Membrane
Extracellular Exosome
Molecular Function
3'-5'-exoribonuclease Activity
RNA Polymerase II Activating Transcription Factor Binding
RNA Binding
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Protein Binding
Biological Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Immune Response
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Protein-containing Complex Assembly
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Interacting Genes
20 interacting genes:
CHMP4B
CSNK2A1
DDX39A
DDX39B
DIS3
EXOSC1
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
HBS1L
MPHOSPH6
MTREX
PALS2
SUMO2
UBE2I
ZDHHC17
30 interacting genes:
AATF
ABCA1
ARHGAP18
DIS3
DNM2
DYNLRB1
EIF3G
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FTL
KHDRBS1
KNSTRN
LIN7A
LIN7B
LIN7C
MT2P1
MTREX
NDN
NFKB1
PARN
RPS20
SMARCA4
SNX9
THOP1
Entrez ID
5393
51678
HPRD ID
07315
09509
Ensembl ID
ENSG00000123737
ENSG00000105926
Uniprot IDs
B4DXG8
Q06265
A0A024RA25
B8ZZG1
Q9NZW5
PDB IDs
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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