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EXOSC9 and EXOSC8
Data Source:
HPRD
(two hybrid, in vivo)
EXOSC9
EXOSC8
Description
exosome component 9
exosome component 8
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nuclear Chromosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Extracellular Exosome
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Molecular Function
3'-5'-exoribonuclease Activity
RNA Polymerase II Activating Transcription Factor Binding
RNA Binding
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Identical Protein Binding
Biological Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Immune Response
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Biological_process
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Interacting Genes
20 interacting genes:
CHMP4B
CSNK2A1
DDX39A
DDX39B
DIS3
EXOSC1
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
HBS1L
MPHOSPH6
MTREX
PALS2
SUMO2
UBE2I
ZDHHC17
74 interacting genes:
AEN
ATF2
C22orf39
CCDC28A-AS1
CNNM3
COL23A1
COX5A
CRMP1
CWC22
DDIT4L
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM161B
FAM90A1
FHOD1
FOXD4L1
FOXN3
FRG1
GEM
HAPLN2
HOXB9
INCA1
KANK2
KCNJ11
LMO4
LNX1
LSM1
LSM4
LSM7
MACIR
MKRN1
MORN4
MPHOSPH6
MTREX
MYOZ1
NEDD9
NTAQ1
OTUD4
PALS2
PHF21A
PIAS2
POLDIP3
RASD1
RASSF1
REL
RFC5
RPP14
RUSC1
RXRB
SLAIN1
SNAI1
SNRPB
SNRPC
SOCS7
SPATC1L
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP2
USP6
XRN1
XRN2
ZFP36
Entrez ID
5393
11340
HPRD ID
07315
09351
Ensembl ID
ENSG00000123737
ENSG00000120699
Uniprot IDs
B4DXG8
Q06265
Q96B26
PDB IDs
2NN6
6D6Q
6D6R
6H25
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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