PALS2 and DIS3

Data Source:
HPRD (in vivo)

		PALS2	DIS3
Description		protein associated with LIN7 2, MAGUK family member	DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytosol Membrane
	Molecular Function	Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Endonuclease Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Protein-containing Complex Assembly	RRNA Processing RRNA Catabolic Process Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA Regulation Of Catalytic Activity CUT Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Restless legs syndrome ( 29029846)
Interacting Genes		30 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A LIN7B LIN7C MT2P1 MTREX NDN NFKB1 PARN RPS20 SMARCA4 SNX9 THOP1	12 interacting genes: EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 MTREX NTMT1 PALS2 ZBTB17
Entrez ID		51678	22894
HPRD ID		09509	06338
Ensembl ID		ENSG00000105926	ENSG00000083520
Uniprot IDs		A0A024RA25 B8ZZG1 Q9NZW5	G3V1J5 Q9Y2L1
PDB IDs			6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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