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EXOSC9 and MPHOSPH6
Data Source:
BioGRID
(pull down, genetic interference)
EXOSC9
MPHOSPH6
Description
exosome component 9
M-phase phosphoprotein 6
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nuclear Chromosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Extracellular Exosome
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Molecular Function
3'-5'-exoribonuclease Activity
RNA Polymerase II Activating Transcription Factor Binding
RNA Binding
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
RNA Binding
Protein Binding
Biological Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Immune Response
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Maturation Of 5.8S RRNA
RRNA Processing
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Leukocyte telomere length (
32109421
31171785
)
Lung adenocarcinoma (
28604730
)
Nevus count or cutaneous melanoma (
32341527
)
Obesity-related traits (
23251661
)
Seasonality and depression (
30217971
)
Interacting Genes
20 interacting genes:
CHMP4B
CSNK2A1
DDX39A
DDX39B
DIS3
EXOSC1
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
HBS1L
MPHOSPH6
MTREX
PALS2
SUMO2
UBE2I
ZDHHC17
32 interacting genes:
AATF
APLP1
ARHGAP18
DNM2
DYNLRB1
EIF3G
ERG28
EXOSC1
EXOSC10
EXOSC3
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FTL
GDF9
HSPB1
KNSTRN
LRIF1
MTREX
NUPR1
PARN
RBM48
RPS20
SMARCA4
SNX9
THOP1
TLE1
TP53
UNC119
ZHX1
Entrez ID
5393
10200
HPRD ID
07315
16111
Ensembl ID
ENSG00000123737
ENSG00000135698
Uniprot IDs
B4DXG8
Q06265
H3BNT4
Q99547
PDB IDs
2NN6
6D6Q
6D6R
6H25
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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