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EXOSC9 and EXOSC1
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
EXOSC9
EXOSC1
Description
exosome component 9
exosome component 1
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nuclear Chromosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Extracellular Exosome
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Molecular Function
3'-5'-exoribonuclease Activity
RNA Polymerase II Activating Transcription Factor Binding
RNA Binding
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Immune Response
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
RRNA Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Blood protein levels (
30072576
)
Early spontaneous preterm birth (
31194736
)
Spontaneous preterm birth with premature rupture of membranes (
31194736
)
Interacting Genes
20 interacting genes:
CHMP4B
CSNK2A1
DDX39A
DDX39B
DIS3
EXOSC1
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
HBS1L
MPHOSPH6
MTREX
PALS2
SUMO2
UBE2I
ZDHHC17
34 interacting genes:
A2M
APP
ASB9
CDC37
DDIT4L
DMRTB1
ECSIT
EXOC6
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FHL3
KCTD1
LNX1
LSM3
MAST1
MPHOSPH6
NOS3
NUP160
PAK5
PTEN
RBPMS
REL
RNF32
SH3GLB2
TCF4
TEX11
UPF2
XRN1
ZNF143
ZNF76
Entrez ID
5393
51013
HPRD ID
07315
16223
Ensembl ID
ENSG00000123737
ENSG00000171311
Uniprot IDs
B4DXG8
Q06265
B1AMU3
Q9Y3B2
PDB IDs
2NN6
6D6Q
6D6R
6H25
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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