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EXOSC9 and EXOSC4
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, proximity labelling technology)
HPRD
(in vivo, two hybrid)
EXOSC9
EXOSC4
Description
exosome component 9
exosome component 4
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nuclear Chromosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Extracellular Exosome
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Transcriptionally Active Chromatin
Intracellular Membrane-bounded Organelle
Molecular Function
3'-5'-exoribonuclease Activity
RNA Polymerase II Activating Transcription Factor Binding
RNA Binding
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
3'-5'-exoribonuclease Activity
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Biological Process
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
Immune Response
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Positive Regulation Of Transcription By RNA Polymerase II
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Maturation Of 5.8S RRNA
Nuclear-transcribed MRNA Catabolic Process
RRNA Processing
RRNA Catabolic Process
Positive Regulation Of Cell Growth
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U4 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
DNA Deamination
Defense Response To Virus
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Polyadenylation-dependent SnoRNA 3'-end Processing
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Asthma (
31959851
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Interacting Genes
20 interacting genes:
CHMP4B
CSNK2A1
DDX39A
DDX39B
DIS3
EXOSC1
EXOSC2
EXOSC3
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
HBS1L
MPHOSPH6
MTREX
PALS2
SUMO2
UBE2I
ZDHHC17
33 interacting genes:
AKR1A1
DIS3
DXO
EEF1A1
EXOSC1
EXOSC10
EXOSC2
EXOSC3
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FAHD1
GADD45GIP1
GTF2IRD1
HBS1L
HNRNPD
LNX1
LRRC8D
MPZL1
MTREX
NEK1
PALS2
POLE2
PPARA
PTEN
SDCBP
SKIV2L
SMPD4
TSEN15
UPF1
UPF2
UPF3B
Entrez ID
5393
54512
HPRD ID
07315
16221
Ensembl ID
ENSG00000123737
ENSG00000178896
Uniprot IDs
B4DXG8
Q06265
Q9NPD3
PDB IDs
2NN6
6D6Q
6D6R
6H25
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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