PALS2 and PARN

Data Source:
BioGRID (two hybrid)

		PALS2	PARN
Description		protein associated with LIN7 2, MAGUK family member	poly(A)-specific ribonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding	3'-5'-exoribonuclease Activity RNA Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding
	Biological Process	Protein-containing Complex Assembly	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA RNA 3'-end Processing Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Positive Regulation Of Telomerase Activity Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Telomerase RNA Stabilization NcRNA Deadenylation Regulation Of Telomerase RNA Localization To Cajal Body
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Diseases
GWAS			Age at voice drop ( 27182965) Height ( 25429064) Male-pattern baldness ( 27182965) Menarche (age at onset) ( 27182965) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		30 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A LIN7B LIN7C MT2P1 MTREX NDN NFKB1 PARN RPS20 SMARCA4 SNX9 THOP1	6 interacting genes: KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2
Entrez ID		51678	5073
HPRD ID		09509	07250
Ensembl ID		ENSG00000105926	ENSG00000140694
Uniprot IDs		A0A024RA25 B8ZZG1 Q9NZW5	A0A494C0Q2 A0A494C1K5 B3KN69 O95453
PDB IDs			2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?
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