Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
EXOSC1 and ZNF143
Data Source:
BioGRID
(two hybrid)
EXOSC1
ZNF143
Description
exosome component 1
zinc finger protein 143
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nucleoplasm
Molecular Function
RNA Binding
Exoribonuclease Activity
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Metal Ion Binding
Biological Process
RRNA Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase III
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase III
Positive Regulation Of SnRNA Transcription By RNA Polymerase II
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Early spontaneous preterm birth (
31194736
)
Spontaneous preterm birth with premature rupture of membranes (
31194736
)
Cutaneous squamous cell carcinoma (
32041948
)
Height (
31562340
)
Hip circumference (
28552196
)
Interacting Genes
34 interacting genes:
A2M
APP
ASB9
CDC37
DDIT4L
DMRTB1
ECSIT
EXOC6
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FHL3
KCTD1
LNX1
LSM3
MAST1
MPHOSPH6
NOS3
NUP160
PAK5
PTEN
RBPMS
REL
RNF32
SH3GLB2
TCF4
TEX11
UPF2
XRN1
ZNF143
ZNF76
21 interacting genes:
EAF1
ENKD1
EXOSC1
FAM90A1
FHL2
IL16
IQUB
LIN54
LMO1
LMO3
NUDT22
POGZ
SNRPB
SPANXN3
SUOX
TAB2
TCAF1
TSC22D2
YJU2
ZNF438
ZNF512B
Entrez ID
51013
7702
HPRD ID
16223
04578
Ensembl ID
ENSG00000171311
ENSG00000166478
Uniprot IDs
B1AMU3
Q9Y3B2
P52747
PDB IDs
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?