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EXOSC1 and EXOSC7
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
EXOSC1
EXOSC7
Description
exosome component 1
exosome component 7
Image
GO Annotations
Cellular Component
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleoplasm
Nucleolus
Cytosol
Molecular Function
RNA Binding
Exoribonuclease Activity
Protein Binding
3'-5'-exoribonuclease Activity
RNA Binding
Exoribonuclease Activity
Protein Binding
Biological Process
RRNA Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
RNA Catabolic Process
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Blood protein levels (
30072576
)
Early spontaneous preterm birth (
31194736
)
Spontaneous preterm birth with premature rupture of membranes (
31194736
)
Acne (severe) (
24927181
)
Cerebrospinal fluid t-tau:AB1-42 ratio (
30153862
)
Interacting Genes
34 interacting genes:
A2M
APP
ASB9
CDC37
DDIT4L
DMRTB1
ECSIT
EXOC6
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC8
EXOSC9
FHL3
KCTD1
LNX1
LSM3
MAST1
MPHOSPH6
NOS3
NUP160
PAK5
PTEN
RBPMS
REL
RNF32
SH3GLB2
TCF4
TEX11
UPF2
XRN1
ZNF143
ZNF76
18 interacting genes:
APP
DIS3
DXO
ESRRG
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC8
EXOSC9
IP6K1
MPHOSPH6
MTREX
PALS2
PTEN
UBE2K
Entrez ID
51013
23016
HPRD ID
16223
09401
Ensembl ID
ENSG00000171311
ENSG00000075914
Uniprot IDs
B1AMU3
Q9Y3B2
A0A024R2T3
B2RDZ9
Q15024
PDB IDs
2NN6
6D6Q
6D6R
6H25
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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