MPHOSPH6 and ARHGAP18

Data Source:
HPRD (two hybrid)

		MPHOSPH6	ARHGAP18
Description		M-phase phosphoprotein 6	Rho GTPase activating protein 18
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol	Ruffle Cytoplasm Cytosol Cytoplasmic Microtubule Plasma Membrane Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	GTPase Activator Activity Cadherin Binding
	Biological Process	Maturation Of 5.8S RRNA RRNA Processing	Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Motility
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Rho GTPase cycle
Drugs
Diseases
GWAS		Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)	Adverse response to chemotherapy (neutropenia/leucopenia) (docetaxel) ( 23648065) Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Axial length ( 24144296) Cognitive function ( 24684796) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes		32 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1	2 interacting genes: MPHOSPH6 PALS2
Entrez ID		10200	93663
HPRD ID		16111	12474
Ensembl ID		ENSG00000135698	ENSG00000146376
Uniprot IDs		H3BNT4 Q99547	Q8N392
PDB IDs		6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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