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PLP1 and CREB3L1
Data Source:
BioGRID
(two hybrid, two hybrid, two hybrid)
PLP1
CREB3L1
Description
proteolipid protein 1
cAMP responsive element binding protein 3 like 1
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Integrin Alphav-beta3 Complex
Myelin Sheath
Synapse
Chromatin
Nucleus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Molecular Function
Structural Molecule Activity
Protein Binding
Structural Constituent Of Myelin Sheath
Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
Protein Binding
CAMP Response Element Binding
SMAD Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Inflammatory Response
Chemical Synaptic Transmission
Axon Ensheathment
Positive Regulation Of Gene Expression
Astrocyte Development
Substantia Nigra Development
Central Nervous System Myelination
Positive Regulation Of Cell Migration
Neuron Projection Development
Long-chain Fatty Acid Biosynthetic Process
Axon Development
AMPA Selective Glutamate Receptor Signaling Pathway
Positive Regulation Of Calcium Ion Transmembrane Transport
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Regulation Of Transcription By RNA Polymerase II
Multicellular Organism Development
Negative Regulation Of Gene Expression
Viral Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Collagen Biosynthetic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Extracellular Matrix Constituent Secretion
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
CREB3 factors activate genes
Drugs
Diseases
Hereditary spastic paraplegia (SPG)
Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Apolipoprotein A1 levels (
32203549
)
Autism spectrum disorder or schizophrenia (
28540026
)
Fasting blood glucose (
22581228
)
HDL cholesterol levels (
32203549
)
LDL cholesterol (
30275531
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Peripheral artery disease (
31285632
)
Schizophrenia (
29483656
)
Systolic blood pressure (
30578418
)
Interacting Genes
86 interacting genes:
ADGRG3
AKT1
AQP10
AQP6
ARL13B
BCL2L13
BIK
CALN1
CALR
CANX
CD40
CD74
CDIPT
CLDN2
CLDN20
CLEC2D
CLN8
CREB3
CREB3L1
CYBC1
DCT
DYSF
EDA2R
ELOVL4
ERGIC3
FAM209A
FCRL2
FFAR2
FNDC9
GAST
GPR42
GPR61
HAS3
HTR2C
IER3IP1
IFITM3
ITGAV
JAGN1
JPH1
KLRC1
LEPROTL1
LEUTX
LHFPL5
LMNA
MAG
MBP
MFF
MGST3
MS4A3
MS4A4A
MTIF3
MUC1
MYADM
NRG1
PI16
PIGP
PTPRN
RELL2
RMDN3
RNF24
SLC10A6
SLC16A2
SLC18A1
SLC1A5
SLC26A6
SLC35E2A
SLC35E3
SLC41A3
SMIM3
SPNS3
STX1A
STX4
SUSD3
TMEM106C
TMEM14B
TMEM182
TMEM242
TMEM243
TMEM254
TMEM31
TMEM45B
TMEM52B
TMEM97
TMPRSS2
UPK2
VAT1
194 interacting genes:
ADAM33
ADGRE2
ADIPOQ
AGPAT3
AGPAT4
AGPAT5
ALG8
ANKRD46
AOC3
APOD
AQP10
AQP2
ARV1
ASGR1
BET1
BMP10
BNIP3
BRICD5
C11orf24
C4orf3
C5
CCL4L2
CD53
CD72
CD99L2
CFHR5
CIAO2A
CLN6
CMTM3
CMTM7
CNIH2
COL8A2
COMT
COX20
CREB3
CREB3L3
CREM
CSGALNACT2
CTSA
CTXN3
CXCL16
CYB561D2
CYBC1
CYP4F2
DDIT3
DOLK
EBP
EMP3
ENTPD3
ERG28
ERMP1
FA2H
FAM3C
FAXDC2
FETUB
FXYD3
FXYD6
GAST
GIMAP1
GIMAP5
GOLT1B
GOSR2
GPR151
GPR25
GPR37L1
HACD2
HIF1A
IL1RL1
INSIG2
ITGAM
JAGN1
KCNK1
LEPROTL1
LHFPL5
LPAR3
LTC4S
MAL
MAL2
MALL
MAN2B2
MARCHF2
MFSD5
MGAM
MGST2
MGST3
MMD2
MS4A1
MS4A13
NAPB
NAT8
NEU1
NINJ1
NINJ2
NRM
NSG1
OLFM4
OR10AG1
ORMDL1
ORMDL2
PAQR6
PEDS1-UBE2V1
PEX16
PGAP2
PGRMC1
PLN
PLP1
PLP2
PLPP4
PLPP6
PLPPR2
PMP22
PRKAB2
PTPN9
RFT1
RHBDD1
RHD
RNASE10
RUNX1T1
RUSF1
SACM1L
SCARF1
SCD
SCGB1D1
SEC22A
SEC22B
SEC61G
SEMA4G
SFXN5
SLC13A2
SLC13A3
SLC16A13
SLC2A3
SLC30A8
SLC35A4
SLC35B1
SLC35B2
SLC35B4
SLC35C2
SLC39A2
SLC39A9
SLC52A1
SLC7A1
SMCO4
SMIM1
SPOCK1
SQLE
STX3
STX7
STX8
SYNGR1
SYNJ2BP
TECR
TEX264
TFRC
TIMM23
TIMMDC1
TLCD1
TMBIM6
TMEM11
TMEM120B
TMEM128
TMEM147
TMEM14A
TMEM14B
TMEM14C
TMEM19
TMEM203
TMEM208
TMEM218
TMEM222
TMEM229B
TMEM234
TMEM239
TMEM50B
TMEM86A
TMIE
TNF
TNFRSF10C
TNMD
TRAM1L1
TSPAN2
TSPO
TSPO2
UBIAD1
UNC93B1
VAMP1
VAMP2
VEZT
VKORC1
WFDC2
YIPF6
ZDHHC15
ZDHHC22
ZFPL1
Entrez ID
5354
90993
HPRD ID
02321
16751
Ensembl ID
ENSG00000123560
ENSG00000157613
Uniprot IDs
A0A0S2Z4D4
A8K9L3
B4DI30
P60201
B2RA75
Q96BA8
PDB IDs
2XPG
Enriched GO Terms of Interacting Partners
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