CREB3L1 and MAL2

Data Source:
BioGRID (two hybrid)

		CREB3L1	MAL2
Description		cAMP responsive element binding protein 3 like 1	mal, T cell differentiation protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Endomembrane System Integral Component Of Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding CAMP Response Element Binding SMAD Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Negative Regulation Of Gene Expression Viral Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Myelination Transcytosis
Pathways		CREB3 factors activate genes
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) HDL cholesterol levels ( 32203549) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Systolic blood pressure ( 30578418)	Blood pressure (smoking interaction) ( 25189868) Gallstone disease ( 30504769) Hippocampal atrophy ( 19668339) Osteoprotegerin levels ( 25080503)
Interacting Genes		194 interacting genes: ADAM33 ADGRE2 ADIPOQ AGPAT3 AGPAT4 AGPAT5 ALG8 ANKRD46 AOC3 APOD AQP10 AQP2 ARV1 ASGR1 BET1 BMP10 BNIP3 BRICD5 C11orf24 C4orf3 C5 CCL4L2 CD53 CD72 CD99L2 CFHR5 CIAO2A CLN6 CMTM3 CMTM7 CNIH2 COL8A2 COMT COX20 CREB3 CREB3L3 CREM CSGALNACT2 CTSA CTXN3 CXCL16 CYB561D2 CYBC1 CYP4F2 DDIT3 DOLK EBP EMP3 ENTPD3 ERG28 ERMP1 FA2H FAM3C FAXDC2 FETUB FXYD3 FXYD6 GAST GIMAP1 GIMAP5 GOLT1B GOSR2 GPR151 GPR25 GPR37L1 HACD2 HIF1A IL1RL1 INSIG2 ITGAM JAGN1 KCNK1 LEPROTL1 LHFPL5 LPAR3 LTC4S MAL MAL2 MALL MAN2B2 MARCHF2 MFSD5 MGAM MGST2 MGST3 MMD2 MS4A1 MS4A13 NAPB NAT8 NEU1 NINJ1 NINJ2 NRM NSG1 OLFM4 OR10AG1 ORMDL1 ORMDL2 PAQR6 PEDS1-UBE2V1 PEX16 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 PLPP6 PLPPR2 PMP22 PRKAB2 PTPN9 RFT1 RHBDD1 RHD RNASE10 RUNX1T1 RUSF1 SACM1L SCARF1 SCD SCGB1D1 SEC22A SEC22B SEC61G SEMA4G SFXN5 SLC13A2 SLC13A3 SLC16A13 SLC2A3 SLC30A8 SLC35A4 SLC35B1 SLC35B2 SLC35B4 SLC35C2 SLC39A2 SLC39A9 SLC52A1 SLC7A1 SMCO4 SMIM1 SPOCK1 SQLE STX3 STX7 STX8 SYNGR1 SYNJ2BP TECR TEX264 TFRC TIMM23 TIMMDC1 TLCD1 TMBIM6 TMEM11 TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM19 TMEM203 TMEM208 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM50B TMEM86A TMIE TNF TNFRSF10C TNMD TRAM1L1 TSPAN2 TSPO TSPO2 UBIAD1 UNC93B1 VAMP1 VAMP2 VEZT VKORC1 WFDC2 YIPF6 ZDHHC15 ZDHHC22 ZFPL1	49 interacting genes: ABCG8 AQP6 ARFIP2 ARL13B ATP6V0E1 CD160 CD68 COQ8A CREB3 CREB3L1 ECPAS FAM3A GAD1 GAD2 GJB1 GPR152 HSFX1 HSFX2 MRM1 MTERF3 MUC1 NDRG4 NFAM1 PBX3 PIMREG PITPNC1 POLL PPP1CA PTPN9 RAB37 REEP4 RETREG3 S100B SCN3B SGK1 SH3GL1 SH3GLB1 SHMT2 SLC35C2 SUCLA2 TBRG4 THAP4 TMEM14B TPD52 TPD52L1 TPD52L2 TTPA TUBB VARS2
Entrez ID		90993	114569
HPRD ID		16751	14351
Ensembl ID		ENSG00000157613	ENSG00000147676
Uniprot IDs		B2RA75 Q96BA8	A0A024R9E4 Q969L2
PDB IDs
Enriched GO Terms of Interacting Partners?
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