Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PLP1 and CALR
Data Source:
HPRD
(in vivo, in vitro)
PLP1
CALR
Description
proteolipid protein 1
calreticulin
Image
GO Annotations
Cellular Component
Plasma Membrane
Integrin Alphav-beta3 Complex
Myelin Sheath
Synapse
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Nucleus
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Polysome
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Phagocytic Vesicle Membrane
Sarcoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
MHC Class I Peptide Loading Complex
Endoplasmic Reticulum Quality Control Compartment
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Endocytic Vesicle Lumen
Molecular Function
Structural Molecule Activity
Protein Binding
Structural Constituent Of Myelin Sheath
Complement Component C1q Complex Binding
DNA Binding
RNA Binding
MRNA Binding
Integrin Binding
Iron Ion Binding
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Carbohydrate Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Hormone Binding
Protein Folding Chaperone
Androgen Receptor Binding
Unfolded Protein Binding
Chaperone Binding
Biological Process
Inflammatory Response
Chemical Synaptic Transmission
Axon Ensheathment
Positive Regulation Of Gene Expression
Astrocyte Development
Substantia Nigra Development
Central Nervous System Myelination
Positive Regulation Of Cell Migration
Neuron Projection Development
Long-chain Fatty Acid Biosynthetic Process
Axon Development
AMPA Selective Glutamate Receptor Signaling Pathway
Positive Regulation Of Calcium Ion Transmembrane Transport
Negative Regulation Of Transcription By RNA Polymerase II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Peptide Antigen Assembly With MHC Class I Protein Complex
Regulation Of Transcription, DNA-templated
Protein Folding
Protein Export From Nucleus
Cellular Calcium Ion Homeostasis
Receptor-mediated Endocytosis
Spermatogenesis
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Translation
Protein Maturation By Protein Folding
Cortical Actin Cytoskeleton Organization
Endoplasmic Reticulum Unfolded Protein Response
Response To Estradiol
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Response To Testosterone
Protein Localization To Nucleus
Protein Folding In Endoplasmic Reticulum
ATF6-mediated Unfolded Protein Response
Regulation Of Meiotic Nuclear Division
Response To Drug
Glucocorticoid Receptor Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Phagocytosis
Protein Stabilization
Sequestering Of Calcium Ion
Cardiac Muscle Cell Differentiation
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Lithium Ion
Cellular Senescence
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Trophoblast Cell Migration
Positive Regulation Of NIK/NF-kappaB Signaling
Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Positive Regulation Of Dendritic Cell Chemotaxis
Pathways
ER-Phagosome pathway
Assembly of Viral Components at the Budding Site
Scavenging by Class A Receptors
Scavenging by Class A Receptors
Scavenging by Class F Receptors
Scavenging by Class F Receptors
ATF6 (ATF6-alpha) activates chaperone genes
Calnexin/calreticulin cycle
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Antihemophilic factor, human recombinant
Tenecteplase
Melatonin
Lanoteplase
Copper
Calcium citrate
Calcium Phosphate
Lonoctocog alfa
Moroctocog alfa
Calcium phosphate dihydrate
Diseases
Hereditary spastic paraplegia (SPG)
Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS
Clozapine-induced agranulocytosis (
25187353
)
Estimated glomerular filtration rate (
31152163
)
Platelet count (
32888494
)
Red blood cell traits (
23222517
)
Interacting Genes
86 interacting genes:
ADGRG3
AKT1
AQP10
AQP6
ARL13B
BCL2L13
BIK
CALN1
CALR
CANX
CD40
CD74
CDIPT
CLDN2
CLDN20
CLEC2D
CLN8
CREB3
CREB3L1
CYBC1
DCT
DYSF
EDA2R
ELOVL4
ERGIC3
FAM209A
FCRL2
FFAR2
FNDC9
GAST
GPR42
GPR61
HAS3
HTR2C
IER3IP1
IFITM3
ITGAV
JAGN1
JPH1
KLRC1
LEPROTL1
LEUTX
LHFPL5
LMNA
MAG
MBP
MFF
MGST3
MS4A3
MS4A4A
MTIF3
MUC1
MYADM
NRG1
PI16
PIGP
PTPRN
RELL2
RMDN3
RNF24
SLC10A6
SLC16A2
SLC18A1
SLC1A5
SLC26A6
SLC35E2A
SLC35E3
SLC41A3
SMIM3
SPNS3
STX1A
STX4
SUSD3
TMEM106C
TMEM14B
TMEM182
TMEM242
TMEM243
TMEM254
TMEM31
TMEM45B
TMEM52B
TMEM97
TMPRSS2
UPK2
VAT1
50 interacting genes:
APOB
APP
AR
B2M
CD1D
F5
F8
FBN1
FGB
GSC2
HLA-A
HLA-C
HLA-E
ITGA2B
ITGA3
ITGAV
LPL
LRIF1
LRP1
MAPK6
MBL2
MTNR1A
NKX2-1
NR3C1
PDIA2
PDIA3
PLAT
PLP1
PRF1
PTPN11
RNY1
RNY3
RNY4
SCARF1
SGTB
SIRPA
SLC2A1
SLC6A4
SMARCB1
SQSTM1
SUMO4
TAF1B
TAPBP
TF
THBS1
TRIM21
TSHR
UBE3A
UPF2
VWF
Entrez ID
5354
811
HPRD ID
02321
00169
Ensembl ID
ENSG00000123560
ENSG00000179218
Uniprot IDs
A0A0S2Z4D4
A8K9L3
B4DI30
P60201
P27797
V9HW88
PDB IDs
2XPG
2CLR
3DOW
3POS
3POW
5LK5
5V90
6ENY
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?