PLP1 and MYADM

Data Source:
BioGRID (two hybrid)

		PLP1	MYADM
Description		proteolipid protein 1	myeloid associated differentiation marker
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integrin Alphav-beta3 Complex Myelin Sheath Synapse	Ruffle Plasma Membrane Cell-cell Junction Integral Component Of Membrane Cortical Actin Cytoskeleton Membrane Raft
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Myelin Sheath	Molecular_function Protein Binding
	Biological Process	Inflammatory Response Chemical Synaptic Transmission Axon Ensheathment Positive Regulation Of Gene Expression Astrocyte Development Substantia Nigra Development Central Nervous System Myelination Positive Regulation Of Cell Migration Neuron Projection Development Long-chain Fatty Acid Biosynthetic Process Axon Development AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transport	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Gene Expression Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Migration Negative Regulation Of Actin Filament Polymerization Membrane Raft Organization Negative Regulation Of Heterotypic Cell-cell Adhesion Cell-cell Junction Maintenance Establishment Of Endothelial Barrier Protein Localization To Plasma Membrane Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
GWAS
Interacting Genes		86 interacting genes: ADGRG3 AKT1 AQP10 AQP6 ARL13B BCL2L13 BIK CALN1 CALR CANX CD40 CD74 CDIPT CLDN2 CLDN20 CLEC2D CLN8 CREB3 CREB3L1 CYBC1 DCT DYSF EDA2R ELOVL4 ERGIC3 FAM209A FCRL2 FFAR2 FNDC9 GAST GPR42 GPR61 HAS3 HTR2C IER3IP1 IFITM3 ITGAV JAGN1 JPH1 KLRC1 LEPROTL1 LEUTX LHFPL5 LMNA MAG MBP MFF MGST3 MS4A3 MS4A4A MTIF3 MUC1 MYADM NRG1 PI16 PIGP PTPRN RELL2 RMDN3 RNF24 SLC10A6 SLC16A2 SLC18A1 SLC1A5 SLC26A6 SLC35E2A SLC35E3 SLC41A3 SMIM3 SPNS3 STX1A STX4 SUSD3 TMEM106C TMEM14B TMEM182 TMEM242 TMEM243 TMEM254 TMEM31 TMEM45B TMEM52B TMEM97 TMPRSS2 UPK2 VAT1	11 interacting genes: C16orf92 CD79A CREB3 ERGIC3 F11R FAM209A LMNA MUC1 PDZK1IP1 PLP1 TMEM106C
Entrez ID		5354	91663
HPRD ID		02321	14792
Ensembl ID		ENSG00000123560	ENSG00000179820
Uniprot IDs		A0A0S2Z4D4 A8K9L3 B4DI30 P60201	A0A024R4N0 Q96S97
PDB IDs		2XPG
Enriched GO Terms of Interacting Partners?
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