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CREB3L1 and DDIT3
Data Source:
BioGRID
(fluorescent resonance energy transfer)
CREB3L1
DDIT3
Description
cAMP responsive element binding protein 3 like 1
DNA damage inducible transcript 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Late Endosome
Cytosol
Protein-DNA Complex
CHOP-C/EBP Complex
CHOP-ATF4 Complex
CHOP-ATF3 Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
Protein Binding
CAMP Response Element Binding
SMAD Binding
Sequence-specific Double-stranded DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
CAMP Response Element Binding Protein Binding
Protein Homodimerization Activity
Leucine Zipper Domain Binding
Protein Heterodimerization Activity
Transcription Regulator Inhibitor Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Regulation Of Transcription By RNA Polymerase II
Multicellular Organism Development
Negative Regulation Of Gene Expression
Viral Process
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Collagen Biosynthetic Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Extracellular Matrix Constituent Secretion
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Maturation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
ER Overload Response
Response To Unfolded Protein
Cell Cycle Arrest
Sensory Perception Of Sound
Anterior/posterior Axis Specification
Regulation Of Autophagy
Wnt Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of CREB Transcription Factor Activity
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Response To Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cell Redox Homeostasis
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Protein Kinase B Signaling
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Negative Regulation Of Determination Of Dorsal Identity
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
CREB3 factors activate genes
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Drugs
Diseases
Myxoid liposarcoma
GWAS
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Apolipoprotein A1 levels (
32203549
)
Autism spectrum disorder or schizophrenia (
28540026
)
Fasting blood glucose (
22581228
)
HDL cholesterol levels (
32203549
)
LDL cholesterol (
30275531
)
Medication use (diuretics) (
31015401
)
Offspring birth weight (
31043758
)
Peripheral artery disease (
31285632
)
Schizophrenia (
29483656
)
Systolic blood pressure (
30578418
)
Brain morphology (MOSTest) (
32665545
)
Interacting Genes
194 interacting genes:
ADAM33
ADGRE2
ADIPOQ
AGPAT3
AGPAT4
AGPAT5
ALG8
ANKRD46
AOC3
APOD
AQP10
AQP2
ARV1
ASGR1
BET1
BMP10
BNIP3
BRICD5
C11orf24
C4orf3
C5
CCL4L2
CD53
CD72
CD99L2
CFHR5
CIAO2A
CLN6
CMTM3
CMTM7
CNIH2
COL8A2
COMT
COX20
CREB3
CREB3L3
CREM
CSGALNACT2
CTSA
CTXN3
CXCL16
CYB561D2
CYBC1
CYP4F2
DDIT3
DOLK
EBP
EMP3
ENTPD3
ERG28
ERMP1
FA2H
FAM3C
FAXDC2
FETUB
FXYD3
FXYD6
GAST
GIMAP1
GIMAP5
GOLT1B
GOSR2
GPR151
GPR25
GPR37L1
HACD2
HIF1A
IL1RL1
INSIG2
ITGAM
JAGN1
KCNK1
LEPROTL1
LHFPL5
LPAR3
LTC4S
MAL
MAL2
MALL
MAN2B2
MARCHF2
MFSD5
MGAM
MGST2
MGST3
MMD2
MS4A1
MS4A13
NAPB
NAT8
NEU1
NINJ1
NINJ2
NRM
NSG1
OLFM4
OR10AG1
ORMDL1
ORMDL2
PAQR6
PEDS1-UBE2V1
PEX16
PGAP2
PGRMC1
PLN
PLP1
PLP2
PLPP4
PLPP6
PLPPR2
PMP22
PRKAB2
PTPN9
RFT1
RHBDD1
RHD
RNASE10
RUNX1T1
RUSF1
SACM1L
SCARF1
SCD
SCGB1D1
SEC22A
SEC22B
SEC61G
SEMA4G
SFXN5
SLC13A2
SLC13A3
SLC16A13
SLC2A3
SLC30A8
SLC35A4
SLC35B1
SLC35B2
SLC35B4
SLC35C2
SLC39A2
SLC39A9
SLC52A1
SLC7A1
SMCO4
SMIM1
SPOCK1
SQLE
STX3
STX7
STX8
SYNGR1
SYNJ2BP
TECR
TEX264
TFRC
TIMM23
TIMMDC1
TLCD1
TMBIM6
TMEM11
TMEM120B
TMEM128
TMEM147
TMEM14A
TMEM14B
TMEM14C
TMEM19
TMEM203
TMEM208
TMEM218
TMEM222
TMEM229B
TMEM234
TMEM239
TMEM50B
TMEM86A
TMIE
TNF
TNFRSF10C
TNMD
TRAM1L1
TSPAN2
TSPO
TSPO2
UBIAD1
UNC93B1
VAMP1
VAMP2
VEZT
VKORC1
WFDC2
YIPF6
ZDHHC15
ZDHHC22
ZFPL1
68 interacting genes:
AMOTL2
ATF2
ATF3
ATF4
ATPAF2
BACH1
BACH2
BATF
BATF2
BATF3
CCDC153
CDK6
CEBPA
CEBPB
CEBPE
CEBPG
CRACR2A
CREB3
CREB3L1
CREBL2
CSNK2A1
DBP
DGCR2
DNMT3L
EMSY
EP300
EPAS1
F2
FOS
FOSL1
FOSL2
GIMAP6
GIPC1
GP1BA
HOXA5
HSD17B14
IKBKG
JDP2
JUN
JUNB
JUND
KPNA2
LMO2
LNX1
MAFF
MAFG
MAPK14
MCMBP
NFIL3
PCM1
PICALM
POLR1D
RAI1
RPS3
RPS3A
SNAPC5
SPOP
SRA1
SSX3
TEDC1
TNFSF12
TRIB3
TXN2
TXNDC2
VPS37C
ZBTB25
ZC3H14
ZSCAN31
Entrez ID
90993
1649
HPRD ID
16751
00529
Ensembl ID
ENSG00000157613
ENSG00000175197
Uniprot IDs
B2RA75
Q96BA8
P35638
Q53YD1
PDB IDs
Enriched GO Terms of Interacting Partners
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