PLD2 and CSK

Data Source:
HPRD (in vivo, in vitro)

		PLD2	CSK
Description		phospholipase D2	C-terminal Src kinase
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Presynapse	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Raft Extracellular Exosome
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Phosphatase Binding Protein Kinase A Catalytic Subunit Binding Identical Protein Binding Metal Ion Binding Proline-rich Region Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility	Adaptive Immune Response Protein Phosphorylation Brain Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance Peptidyl-tyrosine Phosphorylation T Cell Costimulation Negative Regulation Of Interleukin-6 Production Negative Regulation Of Kinase Activity Adherens Junction Organization Negative Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of MAP Kinase Activity Negative Regulation Of Bone Resorption Protein Autophosphorylation Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis	GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling PD-1 signaling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants Negative regulation of FLT3
Drugs		Choline Choline salicylate	Dasatinib Staurosporine TG-100801 Fostamatinib
Diseases
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)	Blood pressure ( 21909110) Blood protein levels ( 30072576) Caffeine consumption ( 21490707) Coffee consumption ( 31959922) Diastolic blood pressure ( 26390057 19430479 19430483) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Hypertension ( 31513605) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Serum albumin level ( 29403010) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Systolic blood pressure ( 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
Interacting Genes		29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL	51 interacting genes: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDC45 CDH5 CREBBP DAB2 DOK1 DOK2 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KANK4 KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PDPK1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 UBE2I ZAP70 ZNF212
Entrez ID		5338	1445
HPRD ID		03857	00496
Ensembl ID		ENSG00000129219	ENSG00000103653
Uniprot IDs		O14939	A8K3B6 B2R6Q4 P41240
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS	1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
Enriched GO Terms of Interacting Partners?
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