Description |
C-terminal Src kinase |
3-phosphoinositide dependent protein kinase 1 |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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- Celecoxib
- Inositol 1,3,4,5-Tetrakisphosphate
- 7-Hydroxystaurosporine
- Bisindolylmaleimide VIII
- Staurosporine
- Bisindolylmaleimide I
- Dexfosfoserine
- 10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
- 5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
- 1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
- 2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
- 3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
- Fostamatinib
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Diseases |
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GWAS |
- Blood pressure ( 21909110)
- Blood protein levels ( 30072576)
- Caffeine consumption ( 21490707)
- Coffee consumption ( 31959922)
- Diastolic blood pressure ( 26390057 19430479 19430483)
- Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
- Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
- Hypertension ( 31513605)
- Lung cancer ( 28604730)
- Lung cancer in ever smokers ( 28604730)
- Mean arterial pressure ( 27618448)
- Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
- Medication use (agents acting on the renin-angiotensin system) ( 31015401)
- Medication use (beta blocking agents) ( 31015401)
- Medication use (diuretics) ( 31015401)
- Offspring birth weight ( 31043758)
- Serum albumin level ( 29403010)
- Systemic lupus erythematosus ( 27399966 26502338 28714469)
- Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
- Systemic sclerosis ( 31672989)
- Systolic blood pressure ( 30578418)
- Systolic blood pressure (cigarette smoking interaction) ( 29455858)
- Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
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Interacting Genes |
51 interacting genes:
ADRB2
ARRB1
CAV1
CD247
CD3E
CD44
CDC45
CDH5
CREBBP
DAB2
DOK1
DOK2
DOK3
FGR
FHL2
FYN
G3BP1
GJA1
GSN
HCK
HNRNPK
ID3
IGF1R
INSR
KANK4
KHDRBS1
LAIR1
LCK
LYN
MAPK15
PAG1
PDPK1
PECAM1
PLD2
PRKACA
PTK2
PTPN12
PTPN18
PTPN22
PXN
RASA1
RGS16
SDC3
SHC1
SIT1
SRC
TGFB1I1
TLR3
UBE2I
ZAP70
ZNF212
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60 interacting genes:
AKT1
AKT2
AKT3
AKTIP
APBB3
APP
BLMH
CARD11
CDAN1
CSK
DDIT4
GIT1
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
LUC7L2
MAPK8
MTOR
PAK1
PEA15
PHAX
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PRXL2B
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SLC9A3R2
SMARCB1
SOCS3
SRC
SRPK1
STRAP
TCAP
WDCP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
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Entrez ID |
1445 |
5170 |
HPRD ID |
00496 |
05556 |
Ensembl ID |
ENSG00000103653
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ENSG00000140992
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Uniprot IDs |
A8K3B6
B2R6Q4
P41240
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O15530
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PDB IDs |
1BYG
1CSK
3D7T
3D7U
3EAC
3EAZ
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1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
4CT1
4CT2
4RQK
4RQV
4RRV
4XX9
5ACK
5HKM
5HNG
5HO7
5HO8
5LVL
5LVM
5LVN
5LVO
5LVP
5MRD
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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