PLD2 and GM2A

Data Source:
HPRD (in vitro)

		PLD2	GM2A
Description		phospholipase D2	GM2 ganglioside activator
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Presynapse	Extracellular Region Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Lipid Transporter Activity Phospholipase Activator Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity
	Biological Process	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility	Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Neutrophil Degranulation Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis	Glycosphingolipid metabolism Neutrophil degranulation
Drugs		Choline Choline salicylate	Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases			GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)	Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)
Interacting Genes		29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL	3 interacting genes: GPLD1 HEXA PLD2
Entrez ID		5338	2760
HPRD ID		03857	02034
Ensembl ID		ENSG00000129219	ENSG00000196743
Uniprot IDs		O14939	P17900
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS	1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?
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