PLD2 and DPYSL2

Data Source:
HPRD (in vitro, in vivo)

		PLD2	DPYSL2
Description		phospholipase D2	dihydropyrimidinase like 2
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Presynapse	Cytosol Microtubule Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity	Dihydropyrimidinase Activity Protein Binding Microtubule Binding Identical Protein Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Axon Guidance Brain Development Regulation Of Axon Extension Regulation Of Neuron Differentiation
Pathways		Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis	CRMPs in Sema3A signaling Recycling pathway of L1
Drugs		Choline Choline salicylate	Artenimol
Diseases
GWAS		Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)	Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL	16 interacting genes: AP2A1 CDC42 CRMP1 DISC1 DPYSL3 DPYSL4 DPYSL5 GORASP2 GSK3B LEF1 NUMB PLD2 ROCK1 TNIK TUBB UBE2I
Entrez ID		5338	1808
HPRD ID		03857	03914
Ensembl ID		ENSG00000129219	ENSG00000092964
Uniprot IDs		O14939	A0A1C7CYX9 Q16555 Q59GB4
PDB IDs		6OHM 6OHO 6OHP 6OHQ 6OHS	2GSE 2VM8 5LXX 5MKV 5MLE 5X1A 5X1C 5X1D 5YZ5 5YZA 5YZB 6JV9 6JVB
Enriched GO Terms of Interacting Partners?
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