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PIK3CB and ALAS1
Data Source:
BioGRID
(two hybrid)
PIK3CB
ALAS1
Description
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5'-aminolevulinate synthase 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Membrane
Midbody
Intracellular Membrane-bounded Organelle
Nucleoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Molecular Function
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Phosphatidylinositol 3-kinase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Phosphatidylinositol Kinase Activity
Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
5-aminolevulinate Synthase Activity
Protein Binding
Pyridoxal Phosphate Binding
Identical Protein Binding
Biological Process
Activation Of MAPK Activity
Regulation Of Cell-matrix Adhesion
Response To Ischemia
Sphingosine-1-phosphate Receptor Signaling Pathway
Phosphatidylinositol Biosynthetic Process
Endocytosis
Autophagy
Chemotaxis
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Axon Guidance
Positive Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Phosphorylation
Cell Migration
Cytokine-mediated Signaling Pathway
Platelet Activation
Positive Regulation Of Neutrophil Apoptotic Process
Positive Regulation Of Rac Protein Signal Transduction
Phosphatidylinositol-3-phosphate Biosynthetic Process
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Negative Regulation Of MAP Kinase Activity
Phosphatidylinositol Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Platelet Aggregation
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Sprouting Angiogenesis
Regulation Of Clathrin-dependent Endocytosis
Response To Hypoxia
Protoporphyrinogen IX Biosynthetic Process
Heme Biosynthetic Process
Mitochondrion Organization
Regulation Of Lipid Metabolic Process
Hemoglobin Biosynthetic Process
Erythrocyte Development
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Heme biosynthesis
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Drugs
Caffeine
XL765
Pyridoxal phosphate
Pyridoxal phosphate
Glycine
Diseases
GWAS
Male-pattern baldness (
28196072
)
Mean platelet volume (
32888494
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
21926972
)
Parkinson's disease (
28892059
)
Schizophrenia (
23974872
)
Interacting Genes
12 interacting genes:
AGTR2
ALAS1
DVL3
HCK
HPS6
LRRK2
MME
PIK3R1
PRKCD
PRKCE
RAB5B
YWHAQ
54 interacting genes:
BCL7A
C2orf42
C8orf33
CAP2
CCHCR1
CDC73
CDK5
CDKN1A
CERK
COBL
DUSP19
EP400
FBXL8
GNL3L
GRXCR1
HSBP1L1
JRK
KIF9
KLHL35
LONRF1
LRRC45
MTFR2
MTSS2
NUDT3
OXTR
PIBF1
PIK3CB
PLAU
POLDIP2
PPL
RAP1B
RNF168
RTL8B
SH2D4A
SNRPB2
SNX20
STAMBP
SUMO2
TCEA2
TEKT4
TK1
TMSB10
TMSB4X
TMSB4XP1
TMSB4XP2
TMSB4XP6
TTC23
USP20
UTP14C
WIPF1
ZFYVE26
ZMAT1
ZNF175
ZNF564
Entrez ID
5291
211
HPRD ID
04234
00505
Ensembl ID
ENSG00000051382
ENSG00000023330
Uniprot IDs
B4DER4
B4DZI3
P42338
B4DVA0
P13196
Q5JAM2
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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